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Protective effect of cinnamaldehyde on nephrotoxicity of aminoglycosides
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Saeideh Naeimi   , Seyedeh Fatemeh Angoshtan , Ali Kani Nejad Moghadam |
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Abstract: (296 Views) |
Introduction: Drug-induced nephrotoxicity is a condition in which kidney injury occurs directly or indirectly by medication which is the third most common cause of acute kidney injury. Drugs can cause approximately 20% of nephrotoxicity. Aminoglycosides are natural or synthetic antibiotics discovered in 1944. Their effectiveness in multi-drug resistant Gram-negative pathogens and satistying bactericidal activity make them a useful class of antibiotics across various aerobic gram-negative organisms. Ototoxicity, nephrotoxicity and rarely peripheral neuropathy, encephalopathy, neuromuscular and autonomic transmission blockade have been identified as some side effects of this class. Cinnamaldehyde is a natural compound with a wide range of biological activities such as antimicrobial, anti-oxidant, anti-tumor, and anti-inflammatory effects. The protective effects of cinnamaldehyde have been investigated in a few studies. There is evidence which shows that cinnamaldehyde has some renoprotective effects and it contains antioxidant properties. In this study, the effect of cinnamaldehyde on nephrotoxicity induced by gentamicin was evaluated.
Methods and Materials: In this study, 24 Wistar rats were divided into four groups (n=6). Group 1: control group (received only normal saline injections), Group 2: injected with gentamicin (100 mg/kg for the last ten days, i.p.), Group 3: injected with cinnamaldehyde (30 mg/kg, ip for 30 days), Group 4: was given cinnamaldehyde (alone for 30 days) and then injected with GM (for 10 days). Urea, creatinine, and superoxide dismutase (SOD) in serum were analyzed.
Results: Increased level of serum urea, creatinine, and decreased level of SOD was observed in the group that received gentamicin. Increasing serum urea and creatinine (p<0.05) have been significantly prevented by coadministration of cinnamaldehyde and gentamicin; a significant increase in the serum activity of superoxide dismutase was observed as compared to the gentamicin group (p<0.05).
Conclusion: The results revealed that gentamicin-induced biochemical alterations in the kidney were decreased significantly by cinnamaldehyde.
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| Keywords: Aminoglycoside, Nephrotoxicity, Cinnamaldehyde |
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Full-Text [PDF 320 kb]
(51 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2023/11/16 | Accepted: 2023/08/23 | Published: 2023/08/23
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