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Investigating the effect of feet electrical stimulation with an intensity of 0.2 milliamperes on the inhibition of epilepsy in newly pentylenetetrazol kindled rats
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Nahid Khodayari   , Nastaran Rodshd Rashii , Mohammad Reza Palizvan |
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Abstract: (295 Views) |
Introduction: Previous results have shown that feet electrical stimulation with a frequency of 3 Hz and a stimulation intensity of 0.2 mA can inhibit the process of kindling in rats. However, this type of electrical stimulation has no effect on kindled rats. The purpose of this research is to investigate a new type of electrical stimulation with a frequency of 100 Hz and an intensity of 0.2 mA on the control of newly developed epilepsy by pentylenetetrazol in rats.
Methods and Materials: Standard PTZ kindling model was induced by PTZ injection (37.5 mg/kg), 13 times at intervals of every 48 hours. To investigate sezure behaviors in animals, their behavior was evaluated up to 20 minutes after drug injection. To this end, male Wistar rats were assigned to 3 groups of animals including control, the group that received 20 minutes of feet electrical stimulation at an intensity of 0.2 and a frequency of 3 Hz and the group that received 20 minutes of feet electrical stimulation at an intensity of 0.2 and a frequency of 100 Hz.
Results: This results showed that the feet electrical stimulation with an intensity of 0.2 milliamps and a frequency of 100 Hz significantly delayed the onset of the 2nd stage of seizures (p<0.05) and increased the time required to reach the 5th stage of seizures (p<0.05). While it had no effect on the stage of attack and the time duration that rats spend in stage 5.
Conclusion: Our findings showed that foot electrical stimulation with intensity of 0.6 and frequency of 100 Hz compared to electrical stimulation with intensity of 0.6 and frequency of 3 Hz and 20 minutes can make inhibition in rats kindled with pentylenetetrazol.
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| Keywords: Epilepsy, electrical stimulation, PTZ |
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Full-Text [PDF 335 kb]
(54 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2023/11/8 | Accepted: 2023/08/23 | Published: 2023/08/23
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