Introduction: Studies have shown that exercise improves memory and alcohol consumption impairs memory. But so far, no study has been conducted on the effect of high-intensity interval training on memory following ethanol consumption. Since oxidative stress can cause memory impairment, the present study aimed to investigate the effect of 8 weeks of high-intensity interval training on hippocampal oxidative stress following ethanol consumption in male rats. Methods and Materials: Male rats were divided into 4 groups: SAL (salin, 1ml/day), ET (ethanol, 1ml/day), EX (exercise) and ET+EX (ethanol and exercise). SAL, ET and ET+EX groups received intragastric gavage, 5 days a week in the first month and 3 days a week in the second month. EX and ET+EX groups do high-intensity interval training 5 days a week for 60 days. The hippocampus was isolated 48 hours after the last training session and the GPX, MDA, TAC and NO factors were measured in it. Results: ET group showed a significant increase in MDA level (P<0.001) compared to SAL group, whereas a significant decrease in MDA level (P<0.001) was shown in EX group compared to SAL group (P<0.05). ET+EX group showed significant decrease in MDA level compared to ET levels (P< 0.05). No significant difference in NO and GPX activity among groups.TAC levels in ET group decreased compared to SAL group (P<0.001) and exercise could significantly increase TAC levels in ET group (P<0.001). Conclusion: Based on our findings, we conclude that High intensity interval exercise following the consumption of Ethanol was able to reduce the levels of oxidants and increase the levels of antioxidants and was effective in improving oxidative stress in the hippocampus, followed by memory and learning.
shirazpour S, Sepehri G, Taheri F, Shahrokhi raeini A, Zangiabadi M, Sheikhi S. The effects of high-intensity interval training on oxidative stress indices in the hippocampus following ethanol consumption in male rats.. Koomesh 2023; 25 (5) :31-31 URL: http://koomeshjournal.semums.ac.ir/article-1-8072-en.html