اکثر مکاتبات کومش از طریق ایمیل سایت می باشد.
لطفا Spam ایمیل خود را نیز چک نمایید.
   [Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 23, Issue 3 (May and June 2021) ::
Koomesh 2021, 23(3): 409-414 Back to browse issues page
Cardiac up-regulation of apolipoprotein D in a rat model of hypo- and hyperthyroidism
Marziyeh Salami , Roghayeh Pakdel , Hamidreza Sameni , Abbas Pakdel , Abbas Ali Vafaei
Abstract:   (302 Views)
Introduction: Cardiac tissue is one of the organs affected by thyroid hormones imbalances. Apolipoprotein D is a multifunctional glycoprotein that is expressed in various tissues including heart tissue. The aim of this study was to evaluate the effect of both hypothyroidism and hyperthyroidism on the level of apolipoprotein D protein in the heart tissue.
Materials and Methods: In order to induce hypothyroidism and hyperthyroidism in white mice, propylthiouracil (PTU, 100 ppm) and levothyroxine (L-T4, 8 ppm) dissolved in water  and were used for 6 weeks, respectively. ELISA method was used to measure the total T3 hormone in rat serum. After confirming the model, the mice were anesthetized and the heart tissue was removed and the ventricle and apex of the heart were used for histological examination. Immunohistochemistry was used to evaluate the expression level of apolipoprotein D.
Results: We showed for the first time that the expression of apolipoprotein D in the hearts of hypothyroid (P<0.05) and hyperthyroid (P<0.001) rats increased significantly compared to the control group.
Conclusion: It is suggested that the increase in cardiac apolipoprotein D levels due to thyroid disorders may be part of an inherent system to protect the heart against damage caused by oxidative stress and inflammation in these disorders.
 
Keywords: Apolipoproteins D, Hyperthyroidism, Hypothyroidism, Thyroid Hormones, Heart
Full-Text [PDF 915 kb]   (236 Downloads)    
Type of Study: Research | Subject: General
Received: 2020/07/26 | Accepted: 2020/11/14 | Published: 2021/05/9
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA

Ethics code: IR.SEMUMS.REC.1397. 148



XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Salami M, Pakdel R, Sameni H, Pakdel A, Vafaei A A. Cardiac up-regulation of apolipoprotein D in a rat model of hypo- and hyperthyroidism. Koomesh. 2021; 23 (3) :409-414
URL: http://koomeshjournal.semums.ac.ir/article-1-6512-en.html


Volume 23, Issue 3 (May and June 2021) Back to browse issues page
کومش Koomesh
Persian site map - English site map - Created in 0.04 seconds with 30 queries by YEKTAWEB 4319