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Design and synthesizing appropriate carrier for release of dexamethasone as an anticancer drug
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Zahra Mirazizi    , Sajedeh Khorshidi , Akbar Karkhaneh |
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Abstract: (4334 Views) |
| Introduction: One of the effective drugs in the treatment of cancer is dexamethasone. Dexamethasone is known as one of the safest glucocorticoid, but there is still side-effects, due to its hydrophobicity and low bioavailability. The purpose of the present study is to design a controlled release carrier for dexamethasone in order to overcome constraints and reduce side effects.
Materials and Methods: In the current experimental study, electrospun fibers were prepared in three Polylactic acid concentrations of 10% (w/v), 14% (w/v) and 18% (w/v) containing 5% (w/v) dexamethasone and were broken by aminolysis process using 1.6 diaminohexan / isopropanol. The morphology of the fibers and broken fibers was evaluated by scanning electron microscopy. The amount of drug loaded and cumulative percentage of drug-released from the broken fibers was determined in 144 h.
Results: The result of fiber morphology evaluation showed that fiber diameter of 18% (w/v) compared to 14% (w/v) and in 14% (w/v) compared to 10% (w/v) increased by 13.1% and 17.5% respectively. Length of broken fibers in sample 18% (w/v) compared to 14% (w/v) and in the sample 14% (w/v) compared to 10% (w/v) decreased by 24.07% and 7.8%, respectively. The drug loading efficacy in broken fibers was 85%. The cumulative release of dexamethasone from the broken fibers increased with increasing polymer concentration.
Conclusion: The design of a polylactic acid non-spherical controlled-release release system with a zero-degree release model can be useful for increasing therapeutic efficacy and reducing the side effects of high-dose dexamethasone.
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| Keywords: Dexamethasone, Neoplasms, Polylactic Acid, Antineoplastic Agents |
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Full-Text [PDF 1206 kb]
(710 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2019/07/16 | Accepted: 2020/01/25 | Published: 2020/05/13
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