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Effects of treadmill exercise and preconditioned bone marrow- derived mesenchymal stem cells transplantation on Aβ-induced neurotoxicity in male rats
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Rokhsareh Abshenas    , Tayebe Artimani , Iraj Amiri , Siamak Shahidi , Rezvan Najafi , Sara Soleimani Asl |
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Abstract: (3566 Views) |
| Introduction: Preconditioning of mesenchymal stem cells (MSCs) is a promising strategy to enhance the therapeutic properties of transplanted MSCs. In this study, we investigated the synergistic effects of treadmill exercise and dimethyloxalylglycine (DMOG)-preconditioned stem cells in an Alzheimer’s disease (AD) model.
Materials and Methods: DMOG- treated MSCs were intravenously transplanted in the AD model and the rats went on treadmill exercise for one month. Thusly, expression of bax, bcl-2, Nrf2, and NQO1 genes were assessed using real- time PCR.
Results: Transplantation of DMOG-treated cells had greater effects on increasing Nrf-2 and NQ1 expression and reducing apoptosis compared to non- treated cells. Ultimately, treadmill exercises for one month along with the transplantation of DMOG- treated cells showed the highest neuroprotective effect.
Conclusion: It seems that the transplantation of DMOG-treated cells beside exercise may have protective effects in the AD model via an increase in antioxidant capacity and a decrease in apoptosis. |
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| Keywords: Exercise, Amyloid, Mesenchymal Stem cells, Oxalylglycine, Antioxidant, Apoptosis |
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Full-Text [PDF 1288 kb]
(693 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2019/05/21 | Accepted: 2019/09/2 | Published: 2020/03/15
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