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Neuroprotective effects of voluntary exercise and hydroalcoholic extraction of Eriobotrya Japonica on dopamine and tyrosine hydroxylase in the striatum of parkinsonian rats
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Ziya Fallahmohammadi   , Akbar Hajizadehmoghadam , Mohammad Aghasi , Amirhossein Esmaeili |
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Abstract: (18743 Views) |
| Introduction: In this study, we investigated the effects of 12 weeks of voluntary
exercise on a running wheel and extraction of plant flowers Eriobotrya Japonica
on dopamine and tyrosine hydroxylase in the striatum of Parkinsonian rats. Materials and Methods: Twenty four rats were divided into three groups: control, Parkinson and
Parkinson + training and extract. To induce Parkinson, 250 mg/kg of 6-hydroxy
dopamine (6-OHDA) (dissolved in saline) was administered into
intracerebrovenricular by a stereotaxic apparatus. Training-extract group were
housed in individual cages with attached running wheels and during study period
received 200 mg/kg extract intraperitoneally three times per week. Tyrosine
hydroxylase and dopamine levels in the striatum were measured by ELISA. Results: Voluntary wheel running and extract significantly prevent the decrease of
dopamine levels in Parkinsonian rats (P = 0.001), but tyrosine hydroxylase
level did not change in training-extract group. Conclusion: Our findings show that
pre-treatment with voluntary exercise and hydroalcoholic extractions of
Eriobotrya Japonica have a protective role against 6-OHDA induced toxicity |
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| Keywords: Eriobotrya japonica, Exercise Therapy, 6-hydroxydopamine, Tyrosine hydroxylase, Dopamine, Striatum, Parkinson |
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Full-Text [PDF 473 kb]
(2384 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2012/11/10 | Accepted: 2013/09/8 | Published: 2013/09/10
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