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Effects of Salvia Sahendica hydroalcoholic extract on PTZ-induced seizure in male mice
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Hassan اژدری زرمهری   , Firozeh نادری , Elaheh ارمی , Mohammad محمدزاده |
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Abstract: (10368 Views) |
| Introduction: Epilepsy
is one of most prevalent disorders of central nervous system that causes sudden
convulsions, transient, repetitive and unpredictable seizures. It affects about
half to one percent of the world population. Historically, herbs have been used
to treat epilepsy. In this study, anti-convulsant effect of Salvia Sahendica
extract was investigated in mice. Materials
and Methods: Sixty
mice were randomly divided into six groups (n=10 in each group). Group one
(control group) was received normal saline and another 5 groups were received
150, 300, 600, 900, 1200 mg/kg of the extract. Thirty minute after peritoneal
injection of different doses of extract or saline, PTZ (85 mg/kg) were injected
and they were immediately transferred to a special cage, and the seizure
parameters were evaluated for 30 minutes. Results: The
injection of the extract had a dose-dependent effect on prolongation of latency
to the onset of clonic and tonic-clonic seizures. The greatest effect was
observed at the dose of 600 mg/kg. Tonic-clonic seizures time in the treated
animals was also reduced. Additionally, it decreased the rate of mortality and
the number of suddenly seizures jumping significantly. Conclusion: The
obtained result showed that the extract of Salvia Sahendica has anticonvulsant
effects. However, more studies are required to understand its action mechanism
and to identify the active components. |
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| Keywords: Mice, Pentylenetetrazole, Seizures, Salvia sahendica |
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Full-Text [PDF 407 kb]
(2215 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2012/06/19 | Accepted: 2013/09/4 | Published: 2013/09/4
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