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Biological health score: an approach to estimate the biological health status in chemical veterans
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Leila Nasiri   , Mohammad-Reza Vaez-Mahdavi , Hossein Hassanpour |
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Abstract: (203 Views) |
Introduction: The long-term complications of sulfur mustard (SM) exposure (which occurred in wars) could arise from the cumulative physiological ‘wear and tear’ systems that are known as allostatic load. This study aimed to apply an extension form of allostatic load score, i.e., biological health score (BHS) to estimate the biological health status in chemical veterans.
Methods and Materials: The plasma samples of two following groups of people were prepared. 1) 442 SM-exposed veterans from Sardasht City. 2) 119 healthy volunteers (control). To estimate BHS, 18 blood-derived biomarkers. These biomarkers included dehydroepiandrosterone sulfate, prolactin, luteinizing hormone, testosterone, hemoglobin, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, total cholesterol, triglycerides, systolic diastolic blood pressure, pulses, C reactive protein, transforming growth factor beta, alanine transaminase, aspartate transaminase, gamma-glutamyltransferase, and creatinine. For each person, the extreme quartile of each biomarker was considered as ‘at risk’ and given the subscore of 1, otherwise, it was scored 0. The total BHS of each person was calculated by summing biomarker-specific scores across all biomarkers.
Results: The BHS was increased (evidence for deterioration of health) in SM-exposed veterans (7.4±2.81) compared to healthy individuals (5.94±2.61) (P<0.001).
Conclusion: The BHS, through measurement of several biomarkers, maybe a reliable index to estimate the biological health status and delayed complications of sulfur mustard-chemical veterans. |
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| Keywords: Biological health score (BHS), allostatic load, sulfur mustard, chemical veterans |
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Full-Text [PDF 404 kb]
(28 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2024/02/24 | Accepted: 2023/08/10 | Published: 2023/08/10
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