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Investigation of the Effect of Borage (Echium amoenum) on Mouse Heart and Hematology Parameters; an In vivo Study
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Saeed Aghebat-Bekheir   , Parisa Sadighara |
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Abstract: (222 Views) |
Introduction: There has been considerable interest in the potential health benefits of borage. Little information is available regarding the safety of this plant. The purpose of this study was to evaluate the impact of borage on the mouse heart.
Methods and Materials: Different amounts of borage extract were injected in mice. The mice were randomly divided into 4 groups including group 1 (Control group without injection), groups 2, 3, and 4 received 12.5 mg/kg, 25 mg/kg, and 50 mg/kg respectively for 28 days. Oxidative stress parameters (lipid peroxidation, total glutathione groups assay, and cupric assay) and biochemical (Creatine kinase activity and total cholesterol) and hematology parameters were evaluated. Furthermore, a histopathology study was carried out on heart tissues.
Results: We found that there was no significant difference in oxidative stress parameters and biochemical parameters between the control group and the groups that received different amounts of borage extract. There were also no changes in the histopathology study. In blood parameters, the level of erythrocytes, hematocrit, and hemoglobin decreased to 50mg/kg, whereas the level of MCH and MCV decreased in high doses.
Conclusion: This article suggested that borage did not cause significant damage to the heart tissue in the mice model. In hematology factors, significant changes were observed in erythrocytes and related parameters. Therefore, the hematotoxicity of consumption of this plant should be considered at high doses.
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| Keywords: borage, cholesterol, heart effect, hematology parameter, oxidative stress |
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Full-Text [PDF 250 kb]
(27 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2024/01/29 | Accepted: 2023/08/1 | Published: 2023/08/1
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