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Fasting attenuates age dependent hypertension: Restoration of the renin–angiotensin system balance and longevity proteins
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Firuzeh Badreh   , Siyavash Joukar Joukar , Mohammad Badavi , Mohammad Rashno |
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Abstract: (280 Views) |
Introduction: Intermittent fasting has emerged as a promising intervention to improve healthspan and attenuate age-related diseases. Specifically, this study aims to investigate the impact of fasting on hypertension, which is a common age-related disease, And also investigated the effects of age of beginning fasting on plasma level of angiotensin II (Ang II), and the expression of Ang II receptors (AT1aR and AT2R) and angiotensin-converting enzyme 2 (ACE2) in the heart and aorta, and expression of klotho, sirtuin1 (SIRT1), and sirtuin3 (SIRT3) as antiaging protein in male Wistar rats.
Methods and Material: Young, middle-aged, and old animals were randomly divided into three subgroups and fed as ad libitum (AL), AL with fasting 1 day per week (FW), and AL with fasting every other day (EOD), respectively, for 3 months.
Results: Aging was associated with high blood pressure, increased levels of Ang II, and imbalances in the expression of AT1aR and AT2R proteins in the heart and aorta. Both EOD and FW feeding were able to decrease blood pressure, Ang II levels (P<0.01, P<0.001), and AT1aR protein expression in the heart (P<0.01, P<0.001) and aorta (P<0.001) of older rats, while increasing AT2R protein expression in the heart and aorta. The expression of ACE2 protein in the heart was also significantly increased with EOD fasting in the old group. Furthermore, EOD feeding was able to recover the defects in the expression of SIRT1 and klotho that occur with aging, and both EOD and FW feeding increased the expression of SIRT3 in middle-aged and old rats.
Conclusion: Older animals have a more desirable response to fasting, particularly with EOD fasting, which improves metabolic factors via the recovery of SIRT1 and klotho. The restoration of the renin-angiotensin system balance mediates the recovery effect of fasting on the cardiovascular system in older rats.
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| Keywords: Intermittent fasting, Blood pressure, Sirtuin, Klotho, Renin-angiotensin system |
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Full-Text [PDF 313 kb]
(31 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2023/12/7 | Accepted: 2023/08/23 | Published: 2023/08/23
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