Introduction: T-2 mycotoxin, makes contamination in food
and feed and causes poisoning in human and livestock. T-2 toxin induces serious
effect on immune system cells. In this study, kinetic of blood peripheral
lymphocyte subsets after T-2 toxin exposure was investigated. Materials and Methods: In this experimental study, sublethal dose of T-2 toxin was
determined and then injected into male mice. 12, 24, 48 and 72 h after toxin injection,
a boold sample was taken from experimental anaimals. Afterward, kinetics of
lymphocyte subpopulations such as CD19+, CD3+, CD4+ and CD8+ cells were analyzed using flow cytometry. Results: Sublethal
dose of T-2 toxin was determined as 2 mg/kg. After sublethal dose injection
CD19+ B cell significantly was decreased at 12 h and was returned to normal
range at 3th day post-injection. CD3+ and CD4+ T populations
increased at 24 h and were returned to normal range at 48 h, but inversely CD8+
T cells was decreased at 12 h and returned to to normal limit at 48 h. Conclusion: Alteration on blood lymphocytes due to T-2 toxin
was occurred in 12 to 24 h post-injection. CD19+ and CD8+ lymphocytes were
sensitive cells to toxin effect. CD3+ and CD4+ populations were increased. This
may be due to pro-inflammatory cytokine release.T-2 toxin has different effects
on kinetic of peripheral blood lymphocyte populations.
Salimian J, Poursasan N, Aziz jalilian F, Kokhaie P, Dalilan S. A kinetic study on changes of mouse peripheral blood lymphocyte subsets after administration of T-2 toxin . Koomesh 1393; 16 (2) :260-265 URL: http://koomeshjournal.semums.ac.ir/article-1-2686-en.html