اکثر مکاتبات کومش از طریق ایمیل سایت می باشد. لطفا Spam ایمیل خود را نیز چک نمایید.
   [Home ] [Archive]   [ فارسی ]  
:: ::
Main Menu
Home::
Journal Information::
Articles archive::
For Authors::
Subscription::
Contact us::
Site Facilities::
Webmail::
Editorial Board::
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
:: Volume 16, Issue 2 (زمستان 1393: 16 (2) 1393) ::
Koomesh 1393, 16(2): 260-265 Back to browse issues page
A kinetic study on changes of mouse peripheral blood lymphocyte subsets after administration of T-2 toxin
Jafar Salimian , Najmeh Poursasan , Farid Aziz jalilian , Parviz Kokhaie , Sona Dalilan
Abstract:   (4463 Views)
 Introduction: T-2 mycotoxin, makes contamination in food and feed and causes poisoning in human and livestock. T-2 toxin induces serious effect on immune system cells. In this study, kinetic of blood peripheral lymphocyte subsets after T-2 toxin exposure was investigated. Materials and Methods: In this experimental study, sublethal dose of T-2 toxin was determined and then injected into male mice. 12, 24, 48 and 72 h after toxin injection, a boold sample was taken from experimental anaimals. Afterward, kinetics of lymphocyte subpopulations such as CD19+, CD3+, CD4+ and CD8+ cells were analyzed using flow cytometry. Results: Sublethal dose of T-2 toxin was determined as 2 mg/kg. After sublethal dose injection CD19+ B cell significantly was decreased at 12 h and was returned to normal range at 3th day post-injection. CD3+ and CD4+ T populations increased at 24 h and were returned to normal range at 48 h, but inversely CD8+ T cells was decreased at 12 h and returned to to normal limit at 48 h. Conclusion: Alteration on blood lymphocytes due to T-2 toxin was occurred in 12 to 24 h post-injection. CD19+ and CD8+ lymphocytes were sensitive cells to toxin effect. CD3+ and CD4+ populations were increased. This may be due to pro-inflammatory cytokine release.T-2 toxin has different effects on kinetic of peripheral blood lymphocyte populations. 
Keywords: Flow cytometry, Kinetics, Lymphocyte subsets, T-2 toxin
Full-Text [PDF 1459 kb]   (1341 Downloads)    
Type of Study: Research | Subject: General
Received: 2014/07/21 | Accepted: 2014/10/22 | Published: 2014/12/15
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Salimian J, Poursasan N, Aziz jalilian F, Kokhaie P, Dalilan S. A kinetic study on changes of mouse peripheral blood lymphocyte subsets after administration of T-2 toxin . Koomesh 1393; 16 (2) :260-265
URL: http://koomeshjournal.semums.ac.ir/article-1-2686-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 16, Issue 2 (زمستان 1393: 16 (2) 1393) Back to browse issues page
کومش Koomesh
Persian site map - English site map - Created in 0.05 seconds with 38 queries by YEKTAWEB 4645