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Ketamine in acute abdominal pain in patients with lead poisoning
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Shaghayegh Rahmani   |
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Abstract: (198 Views) |
Introduction: In this study, we investigated the effect of intravenous ketamine administration on the treatment of acute abdominal pain in lead poisoning patients.
Methods and Materials: In this cross-sectional study, we evaluated 20 patients with opium abuse who were referred to our academic hospital emergency department (ED) with acute abdominal pain. After careful patient selection and absence of known contraindication and complete patient satisfaction, under cardiac monitoring, 0.25 mg/kg ketamine (maximum dose was considered as 20 milligrams) was administered for 30 to 60 seconds. To control ketamine complications 0.03 mg/kg midazolam (maximum dose was considered as 2 milligrams) was injected slowly for one or two minutes. Patients were observed in the ED for the next 6 hours. Pain score was assessed based on VAS with a serial method, before ketamine administration, every hour for the next two hours and every two hours for four hours.
Results: In this study, 20 patients were enrolled with a mean age of 37.2±4.2 years (range from 30 to 44 yrs.). The pain score based on VAS before the ketamine injection was 8.7±0.8. Patients abused opium for 8.1±4.1 years (ranging from (3 to 19 years). The mean ketamine dosage was 14.3±3.4 milligrams (range from 10 to 20 milligrams). Repeated measurement test shows a significant reduction in pain score after ketamine administration (P=0.001). Five patients reported no pain 4 hours after ketamine injection, and 3 of them left the hospital with personal consent. Of the 17 remaining patients, 13 (76.4%) had no pain, and the mean VAS score in the other 4 patients was 1 or 2.
Conclusion: Our results show that single-dose injectable ketamine is one of the best methods with the least side effects to alleviate acute abdominal pain in patients with the drug.
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| Keywords: Ketamine, Lead poisoning, Abdominal pain, Emergency department |
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Full-Text [PDF 230 kb]
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Type of Study: Research |
Subject:
General
Received: 2024/03/5 | Accepted: 2023/08/10 | Published: 2023/08/10
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