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Effect of Rivastigmine on Anxiety in Rat Model of Alzheimer's Disease
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Mohammad Sofiabadi   , Mohammad Hosein Esmaeili , Hashem Haghdoost yazdi |
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Abstract: (331 Views) |
Introduction: Alzheimer's disease (AD) is one of the main causes of disability among the elderly. The rivastigmine, one of the cholinesterase inhibitors (ChEIs), can play a role in its partial treatment. One of the problems of Alzheimer's is anxiety. In this study, the effect of oral rivastigmine on the anxiety behavior of Alzheimer's model rat with STZ was investigated.
Methods and Materials: 32 male rats were used. The study groups included control (Cont), sham and treated with rivastigmine (0.5 and 2 mg/kg). After the i.c.v injection of STZ, the treatment was performed by gavage for 4 weeks. Then, spatial memory and learning (with Morris maze) and anxiety behavior (with plus maze) of rats were evaluated.
Results: AD rat have significantly impaired memory and increased anxiety behavior.
Administering rivastigmine in both doses significantly reduced anxiety-related behavioral changes and improved memory.
Conclusion: Rivastigmine probably reduces anxiety in rats by improving cognitive function and reducing neuropathological changes. |
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| Keywords: Rivastigmine, Anxiety, Alzheimer's disease |
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Full-Text [PDF 253 kb]
(59 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2024/02/26 | Accepted: 2023/08/10 | Published: 2023/08/10
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