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A Review of Antioxidants with Potential Neuroprotective Effects in Traumatic Brain Injury
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Bahareh Hakiminia   |
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Abstract: (267 Views) |
Introduction: Patients with traumatic brain injury (TBI) often suffer from a wide range of physical and cognitive disabilities. Oxidative stress-induced neuronal damage is the main injury mechanism in TBI. In recent decades, several antioxidants have been evaluated to alleviate neuronal damage and improve brain function in TBI. This study is presented with the purpose of reviewing antioxidant agents with potential neuroprotective properties in TBI.
Methods and Materials: In this review article, materials were obtained by searching PubMed, Scopus, Elsevier, Web of Science, and Google Scholar. This search was considered without time limitation.
Results: Antioxidant supplementation is a potential treatment strategy, in which antioxidant agents directly lead to the scavenging of reactive radicals or contribute to the induction of antioxidant defense system. Considering the critical role of oxidative stress in the molecular mechanisms of TBI, researchers have introduced several agents with antioxidant properties as potential candidates for the treatment of TBI. A group of agents such as, coenzyme Q10 (CoQ10), N-acetylcysteine (NAC), flavonoids, vitamin E, ascorbic acid, and omega-3 fatty acids has been reported as neuroprotective agents in preclinical or clinical studies of TBI. Maintenance of blood-brain barrier stability, reduction in edema and oxidative stress, and mitigation of cognitive insufficiencies have been reported as neuroprotective features of these agents. Moreover, alleviation of symptoms, reduction in mortality, and improvement of neurologic scores are the main findings of human studies.
Conclusion: Antioxidant supplementation may be a potential neuroprotective strategy against oxidative damage in TBI patients. However, more studies are needed to clearly confirm the safety and efficacy of these agents. |
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| Keywords: Traumatic brain injury (TBI), Antioxidants |
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Full-Text [PDF 247 kb]
(49 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2024/02/19 | Accepted: 2023/08/1 | Published: 2023/08/1
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