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Pretreatment with a combination of alpha-lipoic acid and mitoQ improves heart function through suppressing the inflammatory pathway in a myocardial infarction model in aged rats
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Samira Nemati   , Abedin Vakili , Reza Badlzadeh , Behnaz Mokhtari , Zohreh Zavvari Oskuye , Soleyman Bafadam |
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Abstract: (239 Views) |
Introduction: Heart attacks, caused by the interruption of blood flow to a part of the heart muscle, are a leading cause of death worldwide, particularly among the elderly. This research explored the potential effect of the combination of alpha lipoic acid and mitoQ, two endogen and mitochondrial powerful antioxidants, to improve myocardial function and the underlying mechanism in an experimental model of myocardial infarction in aged rats.
Methods and Materials: To create a myocardial infarction model in aged rats (24 months), the left anterior descending artery was transiently occluded for 30 minutes and then re-perfused for 24 hours. MitoQ (10 mg/kg) was injected intraperitoneally (IP) once a day for two weeks prior to ischemia and alpha-lipoic acid (100 mg/kg) was administered as gavage for 14 days before ischemia. Subsequently, left ventricular function and inflammatory factors (IL-6, IL-1β, TNF-α) were evaluated 24 hours after ischemia-reperfusion using by ELISA method.
Results: The results of this research show that the administration of alpha-lipoic acid or mito Q alone did not have a beneficial effect in preventing heart damage, but the combined treatment significantly improved cardiac function by reducing the expression of inflammatory factors TNF-α, IL-6, and IL-1β. (P<0.001).
Conclusion: Pretreatment with the combination of alpha-lipoic acid and mito Q protected the heart from ischemia damage in aged rats by inhibiting inflammatory pathways. This compound may be beneficial in preventing and reducing heart damage in elderly individuals who are at risk of heart attack, however, further experimental and clinical studies are needed to confirm this. |
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| Keywords: Myocardial infarction, Inflammatory factors, Alpha lipoic acid, mito Q, Aged rats |
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Full-Text [PDF 336 kb]
(30 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2024/02/11 | Accepted: 2023/08/23 | Published: 2023/08/23
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