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Evaluation of MicroRNA-MicroRNA Network Comprising miR-27a-3p, miR-448, and miR-33b-5p in Peripheral Blood of Patients with Myocardial Infarction
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Saeideh Jafarinejad-Farsangi   , Morteza Hadizadeh |
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Abstract: (214 Views) |
Introduction: MicroRNAs (miRNAs) known to regulate gene expression at the post-transcriptional level and play critical roles in various physiological and pathological processes including cardiovascular diseases. Recent studies have shown that miRNAs can also regulate the non-target mRNAs, a phenomenon referred to as "epitranscriptional regulation". This suggests that miRNAs may have a broader impact on gene expression than previously thought, particularly in the context of complex biological processes such as myocardial infarction (MI).
Methods and Materials: In this study, we investigated direct miRNA-miRNA interactions in whole blood samples from MI patients. Using data from two independent studies (GSE31568 and GSE61741), we identified differentially expressed miRNAs in MI patients and evaluated their interactions with each other using the RNAInter database.
Results: Our results revealed that three miRNAs, miR-27a-3p, miR-448, and miR-33b-5p, directly interacted with eight other differentially-expressed miRNAs. We also conducted an analysis of the gene expression network associated with these interactions to explore potential downstream pathways, which revealed the involvement of events related to the innate immune system and neutrophil activity.
Conclusion: These findings provide new insights into the potential regulatory roles of miRNAs in myocardial infarction and suggest potential targets for future therapeutic interventions.
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| Keywords: miRNA, myocardial infarction, miRNA-miRNA interaction |
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Full-Text [PDF 261 kb]
(31 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2024/02/9 | Accepted: 2023/08/23 | Published: 2023/08/23
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