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Protective Effects of Energy Restriction Diet on Renal Function and Apoptotic Molecules in Acute Kidney Injury
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Zeinab Shahheydaripour   , Alireza Raji‑Amirhasani , Mohammad Khaksari , Mohammad Abbas Bejeshk |
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Abstract: (211 Views) |
Introduction: The health and proper functioning of organs in the human body, including the kidneys, are influenced by people's lifestyles and eating habits. The cellular responses to stressful conditions, such as acute kidney injury (AKI), can be affected by one's diet. The objective of this research is to investigate the effects of energy restriction (ER) diet on the renal function indicators of the kidney and the molecules associated with apoptosis during AKI.
Methods and Materials: Adult male rats were divided into four groups: control group with normal diet, normal diet control group with acute kidney injury, control group with energy restriction diet, acute kidney injury group with energy restriction diet. Animals were placed on an energy-restricted diet for eight weeks. To induce acute kidney injury, animals were subjected to a 24-hour period of water deprivation, followed by administration of hypertonic glycerol solution (50% dissolved in sterile saline) at a dose of 10 ml/kg. At the end of the study, various measurements were performed to evaluate the indicators of kidney function and apoptotic molecules.
Results: In rats with AKI, there was an increase in urinary albumin excretion, serum urea, creatinine levels, and the Bax/Bcl-2 ratio within the kidney, whereas renal estimated glomerular filtration rate (eGFR) decreased. The ER diet demonstrated improvement in renal parameters and prevented an elevation in the Bax/Bcl-2 ratio.
Conclusion: These findings indicate that the ER diet have reno protective effects on AKI, potentially due to their ability to decrease the Bax/Bcl-2 ratio and enhance apoptotic conditions, thereby protecting kidney cells against damage.
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| Keywords: Acute Kidney Injury, Energy Restriction, Apoptosis |
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Full-Text [PDF 324 kb]
(34 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2024/02/5 | Accepted: 2023/08/23 | Published: 2023/08/23
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