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Investigating the effect of Satureja khuzestanica jamzad essential oil on hepatic and renal toxicity induced by subchronic exposure of cypermethrin
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Haniyeh Ranjkeshzadeh   , Rezvan Asgharnejad , Zahra Niknam , Farzaneh Chehelcheraghi , Mahdi Birjandi , Marzieh Rashidi Pour , Rasool Mohammadi , Javad Khalili Fard |
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Abstract: (210 Views) |
Introduction: Pyrethroids are one of the most common insecticides used preferably over organochlorines, organophosphates and carbamates due to their high effectiveness against a wide range of insects and easy biodegradability. Among pyrethroids cypermethrin can induce oxidative stress in liver and kidney. Many plants contain high levels of antioxidants that can play a role in absorbing and neutralizing free radicals. Among these plants Satureja khuzestanica essential oil contains carvacrol with proven antioxidant effects. The current study aimed to assess the protective role of Satureja khuzestanica essential oil (SKEO) in cypermethrin induced hepatic and renal toxicity in male Wistar rats.
Methods and Materials: 28 male Wistar rats were divided into four groups. Group 1 was considered as control, group 2 received SKEO (25 mg/kg), group 3 received cypermethrin (0.02 mg/kg.day), group 4 received cypermethrin (0.02 mg/kg /day) and SKEO (25 mg/kg /day). After sixty consecutive days of treatment the liver and kidney tissues of all rats were obtained for investigating histopathological parameters (Glomerular Basement Membrane Thickness, Hypercellularity, Hyalinosis, Sclerosis for kidney and hepatocytes-change, liver sinusoidal change, necrosis and fibrosis for liver).
Results: The results showed that cypermethrin increase hepatic and renal injury in comparison to control group. Although SKEO did not reduce renal injury but it could significantly reduce liver injury.
Conclusion: It seems that due to various factors such as dose and physicochemical properties which affect tissue concentration and kinetic, SKEO (25 mg/kg/day) has protective effects in liver but not kidney. So we suggest that the optimum dose of SKEO which can effectively protect against multiorgan toxicity induced by cypermethrin can be further studied.
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| Keywords: Satureja khuzestanica Essential oil, Cypermethrin, kidney, liver |
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Full-Text [PDF 262 kb]
(33 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2024/02/3 | Accepted: 2023/08/23 | Published: 2023/08/23
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