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The impact of intraperitoneal tetrahydrocannabinol injection on long-term memory in desert rats
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Adele Naghshbandieh   , Elahe Barfi |
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Abstract: (210 Views) |
Introduction: Tetrahydrocannabinol (THC), the primary psychoactive component of marijuana, can significantly affect the function of the hippocampus, a key region involved in memory processing, leading to behavioral disturbances such as memory and learning impairment. This study aimed to investigate the effect of intraperitoneal THC injection on long-term memory in desert rats.
Materials and Methods: Twenty-four eight-week-old male mice were randomly divided into two groups: a control group and a THC-receiving group. The THC group received the drug intraperitoneally for eight days, and their long-term memory was assessed using the shuttle box test. Data were analyzed using SPSS software, and the mean values of the two groups were compared using the t-test. Significant changes were considered at P<0.05.
Results: The results of the shuttle box test showed a significant decrease in escape latency in the THC group compared to the control group (P<0.05). Additionally, a significant difference was observed in the time spent in the dark area between the THC-treated mice and the control group (P<0.05).
Conclusion: The findings of this study suggest that intraperitoneal THC injection can impair long-term memory in rats.
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| Keywords: Tetrahydrocannabinol, Hippocampus, Long-term memory |
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Full-Text [PDF 252 kb]
(26 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2024/01/22 | Accepted: 2023/08/1 | Published: 2023/08/1
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