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The evaluation of piperine effect on the improvement of memory impairment following traumatic brain injury in rat
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Esmaeil Dalvand   , Hanieh Javid , Hamid Gholami Pourbadie , Hakimeh Gavzan , Mohammad Sayyah |
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Abstract: (249 Views) |
Introduction: Peppers have been used in traditional medicine for a long time and its major component, piperine (PPR), has exhibited antioxidant, anticancer, anti-inflammatory, antihypertensive, hepatoprotective, and neuroprotective properties. The purpose of this study was to investigate the effects of piperine on cognitive impairment in adult male rats after inducing traumatic brain injury (TBI).
Methods and Materials: Spatial learning and memory of rats were assessed by Morris Water Maze during a 5-day training period. After 24 hours, rats were randomly assigned to control, sham, TBI, and PPR groups. Rats of PPR groups received PPR (50mg/kg, dissolved in sesame oil; oral gavage), 30 min after TBI induction and then every 24 hours for seven days. The parameters of escape latency, target quadrant duration, traveled distance, and swimming velocity were measured.
Results: TBI impaired memory acquisition on 8 days post-injury, verified by an increase in the latency to the first platform and a decrease in target quadrant duration in the Morris water maze test. PPR oral administration post-injury attenuated the deteriorative effect of TBI on memory.
Conclusion: Our data show that piperine treatment after brain injury can inhibit cognitive impairment induced by TBI which may make it an effective therapeutic target in post-injury complications.
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| Keywords: Traumatic brain injury, Cognitive dysfunction, Learning and memory, piperine |
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Full-Text [PDF 247 kb]
(37 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2024/01/15 | Accepted: 2023/08/23 | Published: 2023/08/23
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