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A comparison of short-term and long-term effects of lavender alcoholic extract on the oxidative stress system in kainic acid-induced epileptic rats
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Fatemeh Salem   , Batool Rahmati , Farideh Bahrami , Zahra Bahari |
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Abstract: (251 Views) |
Introduction: Among the most common neurological disorders is complex partial epilepsy, especially temporal lobe epilepsy, which causes brain damage and neuronal death. Herbal extracts are suggested as therapeutic methods for treating epilepsy. Traditionally, lavender is used to treat neurological disorders, including epilepsy. It is the objective of this study to investigate how lavender aqueous alcoholic extract affects oxidative stress in seizures caused by kainic acid. Aqueous alcoholic extract of lavender was investigated for its impact on oxidative stress in seizures induced by kainic acid in this study.
Methods and Materials: 80 white male Wistar rats were used in this experiment. The rats were randomly divided into 5 groups in two series of one week and one month. (1) Sham control group (2) Sham group received a 400 mg/kg dose of the extract (3) The epilepsy group received kainic acid (4) The epilepsy group received 400 mg/kg lavender (5) The epilepsy group received 300 mg/kg valproic acid. We examined the effects of lavender on the oxidative stress system after kainic acid injection over the short- and long-term (one month later). Oxidative stress markers superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), malondialdehyde (MDA), nitric oxide (NO) were measured using special ELISA kits.
Results: The injection of kainic acid in the hippocampus region led to a disturbance in the antioxidant system, so that the values of SOD, catalase and glutathione in the presence of kainic acid decreased significantly, but MDA and NO showed a significant increase during one week and one month. The results indicate that the extract has no effect in the short term, but the long-term treatment of one month has been able to prevent the reduction of SOD and catalase. Also, the increase of NO and MDA values did not respond to short-term treatment with the extract, but one-month treatment prevented the significant increase.
Conclusion: Although short-term administration of lavender had no effect on epileptic seizures' disorders of the oxidative stress system, long-term administration of lavender extract was able to alleviate the epileptic symptoms associated with the oxidative stress system.
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| Keywords: Lavender, Oxidative stress, Kainic acid, Seizure |
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Full-Text [PDF 257 kb]
(32 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2024/01/9 | Accepted: 2023/08/23 | Published: 2023/08/23
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