|
Effect of troxerutin consumption during gestation period on reflexive motor behavior in mice offspring
|
Arghavan Bahrami   , Shahin Hassanpour , Morteza Zendedel |
|
|
|
Abstract: (259 Views) |
Introduction: This study aimed to determine the effects of troxerutin consumption during gestation on reflexive motor behavior in mice offspring.
Methods and Materials: Forty pregnant female mice were allocated into four groups. In the control group, mice received water, while in groups 2–4, female mice p.o. administered troxerutin (50, 100, and 150 mg/kg) at 5, 8, 11, 14, and 17 days of gestation (GD). Following delivery, pups were selected based on their experimental group, and reflexive motor behaviors were determined. Also, serum malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPx), and total antioxidant status (TAS) were determined.
Results: Based on the findings, maternal exposure to troxerutin (100 and 150 mg/kg) increased ambulation scores in offspring’s compared with the control group (P < 0.05). Also, prenatal exposure to troxerutin increased front and hind-limb suspension scores in newborns compared with the control group (P < 0.05). Maternal exposure to troxerutin increased grip strength and negative geotaxis in newborns in comparison with control mice (P < 0.05). Prenatal exposure to troxerutin (100 and 150 mg/kg) decreased hind-limb foot angle and surface righting in pups compared with the control group (P < 0.05). Maternal exposure to troxerutin decreased MDA production and increased SOD, GPx, and TAS levels in offspring (P < 0.05).
Conclusion: These results suggested that prenatal consumption of troxerutin improves reflexive motor behaviors in mice pups.
|
|
| Keywords: Gestation period, Mice, Reflexive motor behavior, Troxerutin consumption |
|
|
Full-Text [PDF 320 kb]
(40 Downloads)
|
Type of Study: Research |
Subject:
General
Received: 2024/01/4 | Accepted: 2023/08/23 | Published: 2023/08/23
|
|
|
|
|
|
|
| Send email to the article author |
|
|
|
| Add your comments about this article |
|
|
|
