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Effect of dimethyl itaconate on the behavioral deficit in adult male rats affected by neonatal febrile seizures
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Zohreh Ghotbeddin   , Mohammad Abiri jahromi , Ali Shahriari |
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Abstract: (248 Views) |
Introduction: Seizure is a sudden electrical disorder in the brain. the most important complications are movement, memory and cognitive function impairments. Considering the protective properties of dimethyl itaconate the aim of this research is to investigate the effect of dimethyl itaconate on behavioral disorders in adult male rats affected by fever in their neonatal time.
Methods and Materials: In this study, 10 pregnant rat were used under standard laboratory conditions. their pups were divided into 5 groups, including 1) Control group: no fever. 2) Sham group: received only DMI solvent without inducing fever. 3) fever group: on the 10th day after birth, they were exposed to fever for 30 minutes. 4) DMI group: on the 10th day after birth, they received 20 mg/kg dose (single dose) of DMI. 5) DMI and fever group: one day before inducing fever, they received 20 mg/kg of DMI. To investigate the severity of seizures caused by fever, two parameters of seizure threshold and the number of tonic-clonic seizures were measured. Shuttle box test was used to measure memory, tests for balance and movmant coordination were rotaroad, open field and wire hanging.
Results: The data showed that pretreatment with dimethyl itaconate during neonatal period before inducing fever increased the seizure threshold and decreased the number of tonic-clonic seizures compared to the fever group. Passive memory, movement and balance showed improvement in the DMI + fever group compared to the fever group.
Conclusion: According to the results, it seems that dimethyl itaconate by reduce the number of tonic-clonic seizures and increase the seizure threshold lead to the improvement of behavioral dysfunction in adult male rats affected by fever in their neonatal time.
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| Keywords: Febrile seizure, dimethyl itaconate, behavioral dysfunction, rat |
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Full-Text [PDF 261 kb]
(28 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2024/01/4 | Accepted: 2023/08/23 | Published: 2023/08/23
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