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The effect of Zataria multiflora on respiratory symptoms, inflammatory cytokines and oxidative stress in chronic obstructive pulmonary disease
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Vahideh Ghorani   , Mohammad Hossein Boskabady |
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Abstract: (265 Views) |
ntroduction: Z.multiflora has been long used in traditional medicine to relieve cough in common cold and respiratory tract disorders. Various studies are also reported antioxidant and anti-inflammatory effects of this plant. In the present study, the effects of Z. multiflora extract on respiratory symptoms, inflammatory cytokines and oxidative stress in chronic obstructive pulmonary disease (COPD) patients were evaluated.
Methods and Materials: Forty-one COPD patients were divided to three groups including placebo group (P) and groups treated with 3 and 6 mg/kg/day Z. multiflora extract (Z3 and Z6) for two months. Respiratory symptoms including cough, sputum production, modified medical research council (mMRC) dyspnea scale, forced vital capacity (FVC) and forced expiratory volume in 1s (FEV1), oxidative stress parameters such as malondialdehyde (MDA), superoxide dismutase (SOD) and catalase (CAT) activities as well as TNF-α and IL-8 serum levels were assessed before treatment (step 0), one months (step I) and two months (step II) after treatment.
Results: The cough and mMRC dyspnea scale in both treated groups with Z. multiflora and sputum production only in the Z6-treated group were significantly improved after one and two months treatments compared to baseline values (p<0.01 to p<0.001). FVC and FEV1 were significantly increased during two months treatment with Z3 and Z6 (p<0.05 to p<0.01). IL-8 and TNF-α were significantly decreased after 2-month treatment compared to baseline values in Z3 and Z6 groups (p<0.01). MDA level was significantly decreased after 2-month treatment with Z6 compared with step 0 (p<0.05). SOD and CAT activities in both groups treated with the extract were significantly increased in step II compared with step 0 (p<0.05 to p<0.01).
Conclusion: The results suggest the potential therapeutic effect for this plant on COPD patients which could be due to anti-inflammatory and antioxidant properties.
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| Keywords: Chronic obstructive pulmonary disease, Zataria multiflora, Cytokines, Respiratory symptoms, Oxidative stress |
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Full-Text [PDF 412 kb]
(39 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2023/12/31 | Accepted: 2023/08/23 | Published: 2023/08/23
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