Introduction: Hippocampus plays an important role in cognitive disorders, especially memory, examining hippocampus changes after injury can be a suitable approach for ICH treatment strategies. The purpose of this article is evaluating electrical changes in LTP, inflammation and brain damage in bilateral hippocampus following intracerebral hemorrhage of striatum at different times. Methods and Materials: In this research, 96 male Wistar rats were used (6 control groups and 6 ICH groups). To induce ICH, 100 μL of autologous was injected into the left striatum. Then, on the 3rd, 7th and 14th days after surgery, LTP changes in the ipsilateral and contralateral hippocampus were performed by field potential recording method. After preparing the section and staining with hematoxylin, the volume and number of hippocampal cells were measured. The number of NF-κB positive cells was evaluated by immunohistochemistry method. Results: The changes in LTP amplitude in the hippocampus were seen only on the 7th day after surgery, so in the ICH-7 group, it was significantly decreased in the ipsilateral hippocampus compared to the sham-7 group, while it was significantly increased in the contralateral hippocampus. It shows that the contralateral hippocampus acts compensatory after the induction of ICH. Histology showed a decrease in the number of cells counted in the bilateral hippocampus in the ICH-14 group compared to the sham-14 group. However, hippocampus volume did not change significantly between groups. In immunohistochemical studies, a significant increase in the number of NF-κB positive cells was seen in both hemispheres and in all ICH groups compared to the sham groups. Conclusion: These findings suggest that striatal injury may lead to inflammation and cell death in the bilateral hippocampus, which can impair cognitive function after ICH. Also, changes in NF-κB levels indicated that inflammation is an important factor in long-term hippocampal damage after ICH that can be detected early and therapeutic approaches can be implemented before the onset of delayed disorders.
Vafaee F, Shirzad S, Tayaranian Marvian M, Abroumand Gholami A, Hosseinie M. Changes in long-term potentiation (LTP) and inflammation in the bilateral hippocampus following left hemisphere intracerebral hemorrhage. Koomesh 2023; 25 (5) :225-225 URL: http://koomeshjournal.semums.ac.ir/article-1-8361-en.html