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Investigating the amount of histamine in the uterine tissue after progesterone administration in ovulated stimulated mice in pre-implantation time
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Negar Azadi   , Mandana Beigi Boroujeni , Nasim Beigi Boroujeni , Fatemeh Rasuli |
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Abstract: (248 Views) |
Introduction: In ovulation stimulation methods the daily administration of progesterone is used to stabilize the luteal phase, and its effect on the endometrium and fetus is still under discussion. Considering the process of ovulation stimulation the disruption of the balance of ovarian hormones and the role of histamine in the process of implantation, we knew to conduct a study regarding the effect of ovulation and the administration of progesterone after stimulation of ovulation on the amount of histamine in the uterine tissue.
Methods and Materials: 15 adult female mice were divided into control groups (1), ovulation stimulation (2), and ovulation stimulation with progesterone (3). First, 10 units of HCG were injected intraperitoneally into groups 2 and 3, after 48 hours 10 intraperitoneal units of HMG were administered to groups 2 and 3, and at the same time in all three groups, pseudopregnancy was induced by pulling a vaginal swab and after that, 1 mg of progesterone was injected subcutaneously to group 3 daily for three days. After three and a half days from the uterus, Sampling was done and the amount of histamine in the uterine tissue was measured.
Result: It was observed that the amount of histamine secretion in the progesterone group had a statistically significant difference with the control group and showed a decrease but the amount of histamine in the stimulation group did not have a statistically significant difference with the control group. The amount of histamine secretion from mast cells also decreased between the progesterone and stimulation groups and the statistical difference showed a significant decrease.
Conclusion: It seems that the injection of progesterone has led to a decrease in the secretion of histamine from the uterine tissue, and it can be said that the concentration of progesterone hormone can have an inhibitory effect on the amount of histamine secretion from the uterine tissue.
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| Keywords: Progesterone, Histamine, Uterine, Ovulation stimulation |
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Full-Text [PDF 265 kb]
(35 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2023/12/17 | Accepted: 2023/08/23 | Published: 2023/08/23
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