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A review of herbal medicines effective in the treatment of depression in the last decade
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Himan Mehmannavaz   , Sahel Motaghi |
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Abstract: (252 Views) |
Introduction: Depression is a common mental illness in the world with a mean prevalence of 10.5 percent in developing countries. Since antidepressant drugs are associated with side effects and low efficacy, medicinal plants with natural effective materials with fewer side effects and lower costs can be more effective in the treatment of depression. So, they can be considered as a good choice. Therefore, in this article, we reviewed the medicinal plants that have been studied in the last 10 years and have been effective in treating this disease in animal models, emphasizing on their mechanism of action.
Search Methods: In this study, scientific databases such as Pubmed, SID, Google Scholar, and authentic Persian and Latin articles were used in the years between 2012 and 2023.
Results: Our search showed that the medicinal plants had therapeutic effects on depression symptoms and attenuated symptoms of depression, which are mostly related to the orders of mint, leguminous, fennel, borage, etc. We introduced 40 plants with their mechanisms. Studies have shown that these medicinal plants often exert their anti-depressant effects through the synaptic regulation of serotonin, noradrenaline and dopamine, regulating the activity of the hypothalamus-pituitary-adrenal axis, strengthening the antioxidant defense system and reducing inflammatory mediators.
Conclusion: Nowadays, due to the side effects of antidepressant chemical drugs, high cost, they are less than acceptable among the people and have a contraindications for some people. Therefore, medicinal plants can be a suitable alternative to chemical drugs and can be used.
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| Keywords: Depression, Medicinal Plants, Animal model, Mechanism, Physiology |
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Full-Text [PDF 242 kb]
(37 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2023/12/4 | Accepted: 2023/08/23 | Published: 2023/08/23
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