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The effect of high-intensity interval training on mitochondrial expression of Mir-133 and MiR-15 gene in the heart tissue of rats with myocardial infarction
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Fatemeh Beheshtizadeh   , Mohammad Ali Azarbaijani , Maqsood Piri |
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Abstract: (253 Views) |
Introduction: This study aimed to investigate the effect of HIIT (high-intensity interval training) on the mitochondrial expression of Mir-133 and MiR15 genes in the heart tissue of rats with myocardial infarction.
Methods and Materials: 24 male Wistar rats were divided into healthy and ill groups. After inducing myocardial infarction in 18 male rats using isoproterenol injection, they were randomly assigned to either the HIIT or patient control group. So in total, the study was conducted in three groups. The exercise group underwent 8 weeks of HIIT training, performing at 85-90% VO2 max, 5 days a week. Relative expression of the Mir-133 and MiR-15 genes was obtained by real-time PCR. The data were analyzed by one-way ANOVA and Tukey's post hoc test
Result: The results of a one-way ANOVA revealed a significant difference (p = 0.001) in the mean expression of Mir-133 and MiR-15 genes in the heart muscle of male rats among the three groups. The post hoc test showed a rise in the expression of the Mir-133 gene and a decline in the expression of the MiR-15 gene in rats’ heart muscles in the training group compared to that of the healthy and sick control groups (p = 0.001).
Conclusion: Given the positive effect of HIIT on the number of genes associated with myocardial infarction, it seems that understanding the cellular and molecular processes affected by exercise could make physical activity a simple and targeted treatment option in the future. |
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| Keywords: HIIT, expression of Mir-133 and MiR-15 gene, myocardial infarction |
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Full-Text [PDF 331 kb]
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Type of Study: Research |
Subject:
General
Received: 2023/11/26 | Accepted: 2023/08/23 | Published: 2023/08/23
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