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:: Volume 22, Issue 1 (زمستان 1398) ::
Koomesh 1398, 22(1): 99-106 Back to browse issues page
Dosimetry evaluation of salivary glands in 3D conformal radiotherapy and intensity modulated radiotherapy in oral tongue cancer
Iraj Abedi , Pegah Saadatmand , Hadi Akbari-Zadeh , Alireza Amouheidari , Ahmad Shanei
Abstract:   (3455 Views)
Introduction: The purpose of this study was to evaluate the dosimetric and radiobiological parameters of salivary glands in treatment of patients with oral tongue cancer by 3D conventional radiotherapy (3D-CRT) and intensity modulated radiation therapy (IMRT) techniques. Materials and Methods: This study was performed on treatment planning of patients with oral tongue cancer in T2-3/N0 cancer staging. In this way, the treatment planning was performed on CT images for 3D-CRT and IMRT techniques (with 5, 7 and 9 fields) for all patients. Then, the homogeneity (HI) and conformity index (CI) of dose in the target volume and maximum, mean does of the salivary glands and normal tissue complication probability of parotid glands were computed and compared between different treatment. Results: Results of this study indicated an increase in HI and CI in IMRT compared to 3D-CRT (up to 61.54% and 28.78%). Moreover, the increase in the number of beams in the IMRT technique can lead to decrease in the mean dose of sublingual glands (up to 9.52%) and decrease in the maximum dose of the submandibular glands (up to 6.93%), while, the use of IMRT with 5 and 7 beams can lead to a significant increase in the probability of xerostomia in parotid gland (up to 8.61%) compare with 3D-CRT technique. Conclusion: It can be concluded that IMRT technique with 9 fields led to improve the salivary glands protection, more homogeneity and conformity in the target volume and reducing the received dose of submandibular and sublingual glands compare to the 3D-CRT in patient with oral tongue cancer.  
Keywords: Mouth Neoplasms, Tongue Neoplasm, Conformal Radiotherapy, Intensity-Modulated Radiotherapy, Salivary Glands, Parotid Glands
Full-Text [PDF 1028 kb]   (1011 Downloads)    
Type of Study: Research | Subject: General
Received: 2019/05/23 | Accepted: 2019/08/6 | Published: 2020/01/4
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56. [26] Gay HA, Niemierko A. A free program for calculating EUD-based NTCP and TCP in external beam radiotherapy. Phys Medica 2007; 23: 115-125. [DOI:10.1016/j.ejmp.2007.07.001] [PMID]
57. [27] Emami B. Tolerance of normal tissue to therapeutic radiation. Reports Radiother Oncol 2013; 1.
58. [28] Deasy JO, Moiseenko V, Marks L, Chao KSC, Nam J, Eisbruch A. Radiotherapy dose-volume effects on salivary gland function. Int J Radiat Oncol Biol Phys 2010; 76: S58-63. [DOI:10.1016/j.ijrobp.2009.06.090] [PMID] [PMCID]
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60. [30] McQuaid D, Dunlop A, Nill S, Franzese C, Nutting CM, Harrington KJ, et al. Evaluation of radiotherapy techniques for radical treatment of lateralised oropharyngeal cancers. Strahlentherapie und Onkol 2016; 192: 516-525 [DOI:10.1007/s00066-016-0980-1] [PMID]
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Abedi I, Saadatmand P, Akbari-Zadeh H, Amouheidari A, Shanei A. Dosimetry evaluation of salivary glands in 3D conformal radiotherapy and intensity modulated radiotherapy in oral tongue cancer. Koomesh 1398; 22 (1) :99-106
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