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:: جلد 22، شماره 2 - ( بهار 1399 ) ::
جلد 22 شماره 2 صفحات 220-227 برگشت به فهرست نسخه ها
کنترل تشنج های صرعی با استفاده از تحریکات الکتریکی عمقی مغز با فرکانس کم: مروری بر مکانیسم‌های احتمالی
میثم زارع، امیر شجاعی، سید جواد میرنجفی زاده
چکیده:   (1139 مشاهده)
صرع یکی از شایع‌ترین بیماری‌های عصبی است که هنوز روش قطعی برای درمان آن شناخته نشده است. راه اصلی درمان و کنترل تشنج‌های صرعی دارو‌درمانی است با این حال حدود 20 تا 30 درصد بیماران صرعی نسبت به درمان‌های دارویی مقاوم هستند و نیاز به راه‌های درمانی دیگری دارند. یکی از روش‌های درمانی نوین تحریکات عمقی مغز است. اما هنوز به سؤالاتی اساسی از قبیل این که کدام ناحیه مغزی هدف مناسبی برای تحریک می‌باشد، کدام الگوی تحریک بهترین اثر درمانی را ایجاد می‌کند و مکانیسم احتمالی اثرات ضدتشنجی تحریکات عمقی مغز چیست، پاسخ روشنی داده نشده است. با استفاده از مدل‌های آزمایشگاهی صرع و تشنج نشان داده شده است که تحریکات الکتریکی با فرکانس کم (Low Frequancey Electrical Stimulation, LFS) یکی از الگوهای مؤثر تحریکات عمقی مغز برای کاهش شدت تشنج است. مکانسیم‌های دخیل در ایجاد اثرات ضد تشنجی LFS به طور کامل شناخته نشده است. در این مقاله با مروری بر مطالعات قبلی، به بررسی اثرات ضد تشنجی LFS و مکانیسم‌های احتمالی دخیل در آن و نیز تغییرات مشاهده شده در فعالیت نورون‌های مغزی به دنبال اعمال LFS خواهیم پرداخت.
واژه‌های کلیدی: صرع؛ تحریک عمقی مغز؛ تحریک الکتریکی با فرکانس کم؛ اثر ضد تشنجی
متن کامل [PDF 642 kb]   (179 دریافت)    
نوع مطالعه: مروري | موضوع مقاله: عمومى
دریافت: 1397/11/5 | پذیرش: 1398/3/4 | انتشار: 1398/12/25
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Zare M, Shojaei A, Mirnajarizadeh S J. Control of epileptic seizures by electrical low frequency deep brain stimulation: A review of probable mechanisms. Koomesh. 2020; 22 (2) :220-227
URL: http://koomeshjournal.semums.ac.ir/article-1-5457-fa.html

زارع میثم، شجاعی امیر، میرنجفی زاده سید جواد. کنترل تشنج های صرعی با استفاده از تحریکات الکتریکی عمقی مغز با فرکانس کم: مروری بر مکانیسم‌های احتمالی. كومش. 1399; 22 (2) :220-227

URL: http://koomeshjournal.semums.ac.ir/article-1-5457-fa.html



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