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Protective role of vitamin-D on chronic stress induced-learning and memory deficits in rats
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Sara Choobdar   , Abbas-Ali Vafaei , A. li Rashidy-Pour  , Katayoun Sedaghat |
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Abstract: (4234 Views) |
| Introduction: Long-term stress disturbs HPA axis and increases glucocorticoids release, which disturbs neural plasticity in the hippocampus and may lead to learning and memory deficits. Noticeably, vitamin D plays a protective role in the nervous system and has receptors in the hippocampus. This behavioral study investigates the possible protective role of vitamin-D against the negative effects of chronic stress on learning and memory.
Materials and Methods: All the Rats were randomly divided to two groups stress and control groups (each had 3 subgroups). Stress-group animals were exposed to restraint stress for 28 days, 3 hours/day. During 28 days, vitamin D (5 or 10 mg/kg), or vehicle was injected (IP) twice weekly to both groups. At day 29, blood sample collected for serum corticosterone assay. Morris water maze (MWM) test was performed in the order of 4 days training, one-day probe testing and finally working memory test. Passive avoidance test was performed after MWM.
Results: Stress group revealed higher levels of serum corticosterone (P |
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| Keywords: Chronic Limiting Stress, Hippocampus, Memory, Learning, Vitamin D, Corticosterone, Morris Water Maze, Passive-avoidance Test |
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Full-Text [PDF 2441 kb]
(841 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2018/10/13 | Accepted: 2019/04/30 | Published: 2019/10/29
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