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:: Volume 20, Issue 3 ( Summer 2018) ::
koomesh 2018, 20(3): 575-581 Back to browse issues page
Effects of voluntary exercise on testicular histopathological changes in the offspring of hypothyroid rats
Jafar Amirsadat , Manouchehr Safari , Abbasali Vafaei , Behpour Yousefi , Ali Rashidypour , Hamidreza Sameni *
Abstract:   (143 Views)
Introduction: Thyroid  hormones  play a  key  role  in  the  evolution  of  various  body systems. Relatively, maternal hypothyroidism results in structural and functional changes in the testis by decreasing thyroid hormones. Exercise can potentially improve these changes by increasing thyroid hormones. The purpose of this study was to investigate the effect of voluntary exercise on histopathological changes in testies in children of hypothyroid rats.
Materials and Methods: In this experimental study 40 female Wistar rats were randomly divided into four groups by age 30 days: control-sedentary, control-voluntary exercise, hypothyroidism-sedentary, and hyperthyroidism - voluntary exercise. The total experiments started of the day 30 after birth and ended the day 44 after birth. Hypothyroidism was created using anti-thyroid drug 6-propyl 2-thiouracil from day 6 of pregnancy to day 21 after birth with the addition of the drinking water. At the end of testing, 5 micrometer sections were prepared from the testicle using a microscope equipped with software to analyze the images of tissue were histomorphometry.
Results: Hypothyroidism reduces number of spermatogonia cells, primary spermatocytes cells, leydig cells, and as well as increased sertoli cells in testis.  Hypothyroidism also reduces basement membrane diameter and seminiferous epithelium thickness.  Exercise increases the number spermatogonia cells, primary spermatocytes cells, leydig cells, and as well as reduced sertoli cells in testes. Exercise also increases basement membrane diameter and seminiferous epithelium thickness.
Conclusion: This study showed that exercise is likely to substantially prevent the testis from structural and functional changes due to hypothyroidism.
Keywords: Exercise, Hypothyroidism, Testes, Histopathology, Rat.
Full-Text [PDF 1317 kb]   (27 Downloads)    
Type of Study: Research | Subject: General
Received: 2017/03/9 | Accepted: 2017/12/16 | Published: 2018/06/22
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Amirsadat J, Safari M, Vafaei A, Yousefi B, Rashidypour A, Sameni H. Effects of voluntary exercise on testicular histopathological changes in the offspring of hypothyroid rats. koomesh. 2018; 20 (3) :575-581
URL: http://koomeshjournal.semums.ac.ir/article-1-3901-en.html


Volume 20, Issue 3 ( Summer 2018) Back to browse issues page
کومش Koomesh
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