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Anti-proliferative effects of new synthesized hydrazone derivatives on breast, colon and hepatic cancer cells
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Mehrasa Shademani   , Nasrin Nassiri Koopaei , Nasrin Shirzad Yazdi , Homa Azizian , Zahra Mousavi , Mona Salimi , A. li Almasirad |
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Abstract: (4135 Views) |
| Introduction: Despite the advances made in research on cancer, there is still no effective way to treat this condition. A number of compounds including hydrazone derivatives have been increasingly investigated as anticancer agents. So, in this study a series of novel hydrazone derivatives were designed and synthesized as potential anticancer compounds and their cytotoxic effects were further evaluated.
Materials and Methods: The designed hydrazone compounds (1-9) were synthesized in three steps and their structures were characterized by different instrumental analysis methods. The cytotoxic activity was measured using MTT assay at 48 and 72 h on human breast, colon and liver cancer cell lines.
Results: The obtained percentage of cytotoxicity indicated that some compounds were potent against cancer cell lines and the most effective incubation time was after 72 h of treeatment. Among the synthesized compounds, compounds 3 and 6 revealed the considerable cytotoxic activity on breast, liver and colon cells after 72 h of treatment ranging from 60 to 80%.
Conclusion: The results obtained in this section can be used as the starting point for the development of new cancer chemotherapy agents |
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| Keywords: Cytotoxic, Chemotherapy, Hydrazones, Carcinoma Cell Line, Neoplasms |
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Full-Text [PDF 1335 kb]
(777 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2017/02/10 | Accepted: 2018/05/7 | Published: 2018/09/23
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