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:: Volume 20, Issue 4 (Autumn 2018) ::
koomesh 2018, 20(4): 725-730 Back to browse issues page
Anti-proliferative effects of new synthesized hydrazone derivatives on breast, colon and hepatic cancer cells
Mehrasa Shademani * , Nasrin Nassiri Koopaei , Nasrin Shirzad Yazdi , Homa Azizian , Zahra Mousavi , Mona Salimi , Ali Almasirad
Abstract:   (166 Views)
Introduction: Despite the advances made in research on cancer, there is still no effective way to treat this condition. A number of compounds including hydrazone derivatives have been increasingly investigated as anticancer agents. So, in this study a series of novel hydrazone derivatives were designed and synthesized as potential anticancer compounds and their cytotoxic effects were further evaluated.
Materials and Methods: The designed hydrazone compounds (1-9) were synthesized in three steps and their structures were characterized by different instrumental analysis methods. The cytotoxic activity was measured using MTT assay at 48 and 72 h on human breast, colon and liver cancer cell lines.
Results: The obtained percentage of cytotoxicity indicated that some compounds were potent against cancer cell lines and the most effective incubation time was after 72 h of treeatment. Among the synthesized compounds, compounds 3 and 6 revealed the considerable cytotoxic activity on breast, liver and colon cells after 72 h of treatment ranging from 60 to 80%.
Conclusion: The results obtained in this section can be used as the starting point for the development of new cancer chemotherapy agents
Keywords: Cytotoxic, Chemotherapy, Hydrazones, Carcinoma Cell Line, Neoplasms
Full-Text [PDF 1335 kb]   (24 Downloads)    
Type of Study: Research | Subject: General
Received: 2017/02/10 | Accepted: 2018/05/7 | Published: 2018/09/23
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Shademani M, Nassiri Koopaei N, Shirzad Yazdi N, Azizian H, Mousavi Z, Salimi M et al . Anti-proliferative effects of new synthesized hydrazone derivatives on breast, colon and hepatic cancer cells. koomesh. 2018; 20 (4) :725-730
URL: http://koomeshjournal.semums.ac.ir/article-1-3861-en.html


Volume 20, Issue 4 (Autumn 2018) Back to browse issues page
کومش Koomesh
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