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Effects of reversible inactivation of the orbitofrontal cortex on acquisition and consolidation of spatial memory in place avoidance learning task in rat
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A. A. وفایی   , A. رشیدی پور  , M. R. شریفی , J. بورش |
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Abstract: (14363 Views) |
| Introduction. T he presen t ex pe riment examined the ro le of th e orbitofronta l co rt ex (O FC ) in th e acq u isi t io n an d co ns o lida tion of spa t ia l memory in pl a ce avo id a nce learni ng tas k. Materials and Methods. Ma le Long-Eva ns st rai n ra t s we r e su rgi cally im p la n t e d b ilat e ra lly wi t h ca n n ula e aimed a t th e OFC a n d we r e t ra ine d to a void a 60 d egr e e segme nt of th e a re na en te ring wh ich was punish ed by mild footshoc k. Place avoida nce trainin g oc curr e d in a s in gle 30 -min sessi o n a nd th e av o ida nce memory was asse ssed d uring a 30-min extinction tria l 24 h la te r. The time to th e first entry and th e numbe r of entrances into t he pun ished sect or du r ing e xtin c tion were used to me asure the p la ce avo idance memory. Re te ntio n te st was done one da ys la te r. Results. Results indica ted th at infusio n of TTX 60 min before (acq uisit ion ph ase ) a nd imme d ia te ly a ft e r t r a in ing (co nso lid a t io n p hase ) into O FC s ig nifi can t ly impaired rete nt ion performance. Conclusion. The a bo ve results show th at OFC plays a n important ro le in acq uisitio n and co nso lida t ion of spa tial memory in place avoida nce learning task. |
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| Keywords: Orbitofronta l Cortex, Sp a tia l memory: Reve rsible lnactiva tio nt |
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Full-Text [PDF 1034 kb]
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Type of Study: Research |
Subject:
General
Received: 2009/01/18 | Published: 2000/11/15
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