Koomesh journal
كومش
Koomesh
Medical Sciences
http://koomeshjournal.semums.ac.ir
47
journal47
16087046
10.52547/koomesh
fa
jalali
1389
6
1
gregorian
2010
8
1
12
1
online
1
fulltext
en
بررسی اثرات ورزش ارادی بر شدت علایم قطع مرفین ناشی از نالوکسان در موشهای سفید آزمایشگاهی
Effects of voluntary exercise on severity of naloxone precipitated morphine withdrawal signs in rats
عمومى
General
پژوهشي
Research
Introduction: Addiction is a chronic disorder that requires long-term drug treatments. However, the most drug treatments programs have limited success. The aim of the present study was to investigate the effects of voluntary exercise on naloxone-precipitated morphine withdrawal signs in rats . Materials and Methods: All rats were individually housed in cages with a free access to a running wheel and received subcutaneous injection of saline or morphine (10 mg/kg) twice per day at 12 hr intervals for 10 days. Non-runner groups were confined to the similar cages with no access to the wheels, but treated by morphine or saline. Morphine dependent intensity was examined by acute morphine withdrawal and naloxone injection (2 mg/kg, IP) according to a modified version of the Gellert–Holtzman scale. Results: The results showed that there was no significant differences between control and morphine treated groups in running rates for a period of 10 days, indicating no effect of morphine on running activity. Withdrawal signs including abdominal contractions, wet dog shakes, weight loss (24h) and overall Gellert–Holtzman score were significantly lower in the exercising morphine treated rats as compared with non-exercising control rats (P= 0.0001). Conclusion: Our findings indicated that the physical activity diminishes severity of dependency on morphine. Thus, it could be a potential natural reward method for substituting with the others of care methods.
مورفین، دویدن ارادی، علایم قطع ، نالوکسان، موش سفید آزمایشگاهی
Morphine, Voluntary wheel-running, Withdrawal signs, Naloxone, Rat
86
92
http://koomeshjournal.semums.ac.ir/browse.php?a_code=A-10-9-2&slc_lang=en&sid=1
Hossein
میلادیگرجی
حسین
میلادیگرجی
470031947532846005454
470031947532846005454
No
A. li
رشیدیپور
علی
رشیدیپور
rashidy-pour@sem-ums.ac.ir
470031947532846005558
470031947532846005558
Yes
Yaghoub
فتحاللهی
یعقوب
فتحاللهی
470031947532846005559
470031947532846005559
No
Saeed
سمنانیان
سعید
سمنانیان
470031947532846005560
470031947532846005560
No
Maziar
محمداخوان
مازیار
محمداخوان
470031947532846005561
470031947532846005561
No