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Significance of exosomes in COVID-19 pathogenesis and therapy
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Parviz Basiri    , Mohammad Hasan Soheilifar , Sima Nobari , Amir Hasan Nikfarjam , Hoda Keshmiri Neghab , Saeid Afshar , Shima Ghorbanifar , A. li Mahdavinezhad |
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Abstract: (1992 Views) |
| Exosomes are lipid bilayer-enclosed nano-sized vesicles, which carry various biomolecules including proteins, lipids, and microRNAs. SARS-CoV-2-loaded exosomes can be entered into the susceptible host cells, and transported viral components which are associated with viral particles intercellular transmission and spread of infection. Over-stimulation of the immune system followed by excessive proinflammatory cytokine production is a hallmark of COVID-19. Mesenchymal stem cell-derived exosomes are a potential therapeutic option in COVID-19 due to their ability to decrease cytokine storm, improve tissue regeneration, and prevent multi-organs failure. Unraveling the exact role of exosomes underlying COVID-19 infection will be beneficial in understanding novel aspects of COVID-19 pathogenesis and therapy. This study aimed to investigate the importance of exosomes in COVID-19 |
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| Keywords: SARS-CoV-2, Exosome, COVID-19, Therapy |
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Full-Text [PDF 1006 kb]
(673 Downloads)
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Type of Study: Review |
Subject:
review
Received: 2021/01/6 | Accepted: 2021/05/18 | Published: 2021/11/28
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