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:: Volume 23, Issue 6 (آذر و دی 1400) ::
Koomesh 1400, 23(6): 673-682 Back to browse issues page
Significance of exosomes in COVID-19 pathogenesis and therapy
Parviz Basiri , Mohammad Hasan Soheilifar , Sima Nobari , Amir Hasan Nikfarjam , Hoda Keshmiri Neghab , Saeid Afshar , Shima Ghorbanifar , A. li Mahdavinezhad *
Abstract:   (1552 Views)
Exosomes are lipid bilayer-enclosed nano-sized vesicles, which carry various biomolecules including proteins, lipids, and microRNAs. SARS-CoV-2-loaded exosomes can be entered into the susceptible host cells, and transported viral components which are associated with viral particles intercellular transmission and spread of infection. Over-stimulation of the immune system followed by excessive proinflammatory cytokine production is a hallmark of COVID-19. Mesenchymal stem cell-derived exosomes are a potential therapeutic option in COVID-19 due to their ability to decrease cytokine storm, improve tissue regeneration, and prevent multi-organs failure. Unraveling the exact role of exosomes underlying COVID-19 infection will be beneficial in understanding novel aspects of COVID-19 pathogenesis and therapy. This study aimed to investigate the importance of exosomes in COVID-19
Keywords: SARS-CoV-2, Exosome, COVID-19, Therapy
Full-Text [PDF 1006 kb]   (439 Downloads)    
Type of Study: Review | Subject: review
Received: 2021/01/6 | Accepted: 2021/05/18 | Published: 2021/11/28
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Basiri P, Soheilifar M H, Nobari S, Nikfarjam A H, Keshmiri Neghab H, Afshar S, et al . Significance of exosomes in COVID-19 pathogenesis and therapy. Koomesh 1400; 23 (6) :673-682
URL: http://koomeshjournal.semums.ac.ir/article-1-6841-en.html


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Volume 23, Issue 6 (آذر و دی 1400) Back to browse issues page
کومش Koomesh
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