:: جلد 23، شماره 6 - ( آذر و دی 1400 ) ::
جلد 23 شماره 6 صفحات 719-712 برگشت به فهرست نسخه ها
بررسی تاثیر تجویز ویتامین D بر فاکتورهای استرس اکسیداتیو خون در دانشجویان: یک مطالعه کارآزمایی بالینی تصادفی دوسوکور
فاطمه دباغ زاده ، مریم رحیم پور ، سمیه کرمی مهاجری
چکیده:   (1573 مشاهده)
هدف: کمبود ویتامین D در جهان بسیار گسترده است و در کشورهای اسلامی نیز علی‌رغم وجود نور خورشید کافی رواج دارد. تحقیقات اخیر نشان داده‌اند که کاهش سطح ویتامین D عملکرد میتوکندری را مختل و استرس اکسیداتیو را تقویت می‌کند و منجر به بروز بیماری‌های شایع مانند اختلالات متابولیکی می‌شود. این مطالعه با هدف ارزیابی تأثیر مکمل ویتامین D بر عوامل استرس اکسیداتیو در دانشجویان انجام گردید. مواد و روش‌ها: این مطالعه یک کارآزمایی بالینی تصادفی دوسوکور بود. دانشجویان به طور تصادفی به دو گروه دارونما و درمان با حجم نمونه به ترتیب 26 و 25 نفر در هر گروه تقسیم شدند. دانشجویان دو پرل 50 هزار واحد ویتامین D یا دارونما در زمان شروع درمان و بعد از 4 هفته دریافت کردند. قبل از شروع مطالعه و بعد از 8 هفته، بیومارکرهای استرس اکسیداتیو از جمله ظرفیت تام آنتی‌اکسیدانی پلاسما و پراکسیداسیون لیپیدها در نمونه‌های خون اندازه‌گیری شد. یافته‌ها: در ابتدای مطالعه، تفاوت معنی‌داری بین گروه درمان و دارونما در میانگین ویتامین D وجود نداشت ولی بعد از تجویز ویتامین  D، این تفاوت معنی‌دار شد. ویتامین D در مقایسه با گروه دارونما به طور قابل توجهی ظرفیت آنتی‌اکسیدانی کل را افزایش (019/0=P) و میزان پراکسیداسیون لیپیدها (004/0=P) را کاهش داد. نتیجه‌گیری: نتایج این مطالعه تأثیر تجویز ماهانه 50 هزار واحد ویتامین D را در کاهش عوامل استرس اکسیداتیو دانشجویان نشان می‌دهد.
واژه‌های کلیدی: ویتامین D، دانشجویان، استرس اکسیداتیو، آنتی‌اکسیدان
متن کامل [PDF 1432 kb]   (516 دریافت)    
نوع مطالعه: پژوهشي | موضوع مقاله: عمومى
دریافت: 1399/4/19 | پذیرش: 1400/2/28 | انتشار: 1400/9/7
فهرست منابع
1. [1] DeLuca HF. Overview of general physiologic features and functions of vitamin D. Am J Clin Nutr 2004; 80: 1689S-1696S. [DOI:10.1093/ajcn/80.6.1689S] [PMID]
2. [2] Gunton JE, Girgis CM. Vitamin D and muscle. Bone Rep 2018; 8: 163-167. [DOI:10.1016/j.bonr.2018.04.004] [PMID] [PMCID]
3. [3] Holick MF. Vitamin D status: measurement, interpretation, and clinical application. Ann Epidemiol 2009; 19: 73-78. [DOI:10.1016/j.annepidem.2007.12.001] [PMID] [PMCID]
4. [4] Holick MF. The vitamin D epidemic and its health consequences. J Nutr 2005; 135: 2739S-2748S. [DOI:10.1093/jn/135.11.2739S] [PMID]
5. [5] Zittermann A. Vitamin D and disease prevention with special reference to cardiovascular disease. Prog Biophys Mol Biol 2006; 92: 39-48. [DOI:10.1016/j.pbiomolbio.2006.02.001] [PMID]
6. [6] Sepehrmanesh Z, Kolahdooz F, Abedi F, Mazroii N, Assarian A, Asemi Z, et al. Vitamin D supplementation affects the beck depression inventory, insulin resistance, and biomarkers of oxidative stress in patients with major depressive disorder: a randomized, controlled clinical trial. J Nutr 2016; 146: 243-248. [DOI:10.3945/jn.115.218883] [PMID]
7. [7] Razavi M, Jamilian M, Karamali M, Bahmani F, Aghadavod E, Asemi Z. The effects of vitamin DK-calcium co-supplementation on endocrine, inflammation, and oxidative stress biomarkers in vitamin D-deficient women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. Horm Metab Res 2016; 48: 446-451. [DOI:10.1055/s-0042-104060] [PMID]
8. [8] Polachini CR, Spanevello RM, Zanini D, Baldissarelli J, Pereira LB, Schetinger MR, et al. Evaluation of delta-aminolevulinic dehydratase activity, oxidative stress biomarkers, and vitamin D levels in patients with multiple sclerosis. Neurotox Res 2016; 29: 230-242. [DOI:10.1007/s12640-015-9584-2] [PMID]
9. [9] Anglin RE, Samaan Z, Walter SD, McDonald SD. Vitamin D deficiency and depression in adults: systematic review and meta-analysis. Br J Psychiatry 2013; 202: 100-107. [DOI:10.1192/bjp.bp.111.106666] [PMID]
10. [10] Dong JY, Zhang W, Chen JJ, Zhang ZL, Han SF, Qin LQ. Vitamin D intake and risk of type 1 diabetes: a meta-analysis of observational studies. Nutrients 2013; 5: 3551-3562. [DOI:10.3390/nu5093551] [PMID] [PMCID]
11. [11] Mazahery H, Camargo CA, Conlon C, Beck KL, Kruger MC, von Hurst PR. Vitamin D and autism spectrum disorder: a literature review. Nutrients 2016; 8: 236. [DOI:10.3390/nu8040236] [PMID] [PMCID]
12. [12] Oliveira SR, Simão AN, Alfieri DF, Flauzino T, Kallaur AP, Mezzaroba L, et al. Vitamin D deficiency is associated with disability and disease progression in multiple sclerosis patients independently of oxidative and nitrosative stress. J Neurol Sci 2017; 381: 213-219. [DOI:10.1016/j.jns.2017.07.046] [PMID]
13. [13] Walker VP, Modlin RL. The vitamin D connection to pediatric infections and immune function. Pediatr Res 2009; 65: 106R-113R. [DOI:10.1203/PDR.0b013e31819dba91] [PMID] [PMCID]
14. [14] Bahnam B, Semnani V, Hadadnia F, Mirmohammadkhani M. Vitamin D serum levels in nurses in Semnan educational hospitals and its association with depression. Koomesh 2016; 17: 313-322. (Persian).
15. [15] Semnani V, Farhidzadeh E, Mirmohammadkhani M, Ghahremanfard F. Investigation of blood levels of vitamin D in women with breast cancer and its correlation with prognostic markers. Koomesh 2017; 19: 735-741. (Persian).
16. [16] Sepidarkish M, Farsi F, Akbari-Fakhrabadi M, Namazi N, Almasi-Hashiani A, Maleki Hagiagha A, et al. The effect of vitamin D supplementation on oxidative stress parameters: A systematic review and meta-analysis of clinical trials. Pharmacol Res 2019; 139: 141-152. [DOI:10.1016/j.phrs.2018.11.011] [PMID]
17. [17] Pizzino G, Irrera N, Cucinotta M, Pallio G, Mannino F, Arcoraci V, et al. Oxidative stress: harms and benefits for Human health. Oxid Med Cell Longev 2017; 2017: 8416763. [DOI:10.1155/2017/8416763] [PMID] [PMCID]
18. [18] Belenguer-Varea A, Tarazona-Santabalbina FJ, Avellana-Zaragoza JA, Martinez-Reig M, Mas-Bargues C, Ingles M. Oxidative stress and exceptional human longevity: Systematic review. Free Radic Biol Med 2020; 149: 51-63. [DOI:10.1016/j.freeradbiomed.2019.09.019] [PMID]
19. [19] Alkadi H. A review on free radicals and antioxidants. Infect Disord Drug Targets 2020; 20: 16-26. [DOI:10.2174/1871526518666180628124323] [PMID]
20. [20] Ilahi M, Armas LA, Heaney RP. Pharmacokinetics of a single, large dose of cholecalciferol. Am J Clin Nutr 2008; 87: 688-691. [DOI:10.1093/ajcn/87.3.688] [PMID]
21. [21] Heidari H, Amani R, Feizi A, Askari G, Kohan S, Tavasoli P. Vitamin D supplementation for premenstrual syndrome-related inflammation and antioxidant markers in students with vitamin D deficient: a randomized clinical trial. Sci Rep 2019; 9: 14939. [DOI:10.1038/s41598-019-51498-x] [PMID] [PMCID]
22. [22] Benzie IF, Strain JJ. The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay. Anal Biochem 1996; 239: 70-76. [DOI:10.1006/abio.1996.0292] [PMID]
23. [23] Zeb A, Ullah F. A simple spectrophotometric method for the determination of thiobarbituric acid reactive substances in fried fast foods. J Anal Methods Chem 2016; 2016: 9412767. [DOI:10.1155/2016/9412767] [PMID] [PMCID]
24. [24] Kruger NJ. The Bradford method for protein quantitation. In: Walker JM, editor. The Protein Protocols Handbook. Totowa, NJ: Humana Press; 2009; p: 17-24. [DOI:10.1007/978-1-59745-198-7_4]
25. [25] Bischoff-Ferrari HA, Giovannucci E, Willett WC, Dietrich T, Dawson-Hughes B. Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. Am J Clin Nutr 2006; 84: 18-28. [DOI:10.1093/ajcn/84.1.18] [PMID]
26. [26] Palacios C, Gonzalez L. Is vitamin D deficiency a major global public health problem? J Steroid Biochem Mol Biol 2014; 144: 138-145. [DOI:10.1016/j.jsbmb.2013.11.003] [PMID] [PMCID]
27. [27] Hovsepian S, Amini M, Aminorroaya A, Amini P, Iraj B. Prevalence of vitamin D deficiency among adult population of Isfahan City, Iran. J Health Popul Nutr 2011; 29: 149. [DOI:10.3329/jhpn.v29i2.7857] [PMID] [PMCID]
28. [28] Nakhaee S, Ali Yaghoubi M, Zarban A, Amirabadizadeh A, Faghihi V, Yoosef Javadmoosavi S, et al. Vitamin D deficiency and its associated risk factors in normal adult population of Birjand, Iran. Clin Nutr ESPEN 2019; 32: 113-117. [DOI:10.1016/j.clnesp.2019.04.002] [PMID]
29. [29] Esmaeili SA, Mohammadian S, Radbakhsh S, Momtazi-Borojeni AA, Kheirmand Parizi P, Atabati H, et al. Evaluation of vitamin D3 deficiency: A population-based study in northeastern Iran. J Cell Biochem 2019; 120: 10337-10341. [DOI:10.1002/jcb.28317] [PMID]
30. [30] Toopchizadeh V, Barzegar M, Masoumi S, Jahanjoo F. Prevalence of Vitamin D deficiency and associated risk factors in cerebral palsy a study in North-West of Iran. Iran J Child Neurol 2018; 12: 25-32.
31. [31] Ramezani M, Sadeghi M. The prevalence of Vitamin D deficiency in adults in Kermanshah, Western Iran. Iran J Public Health 2018; 47: 299-300. (Persian).
32. [32] Saki F, Dabbaghmanesh MH, Omrani GR, Bakhshayeshkaram M. Vitamin D deficiency and its associated risk factors in children and adolescents in southern Iran. Public Health Nutr 2017; 20: 1851-1856. [DOI:10.1017/S1368980015001925] [PMID]
33. [33] Pirdehghan A, Vakili M, Dehghan R, Zare F. High prevalence of Vitamin D deficiency and adverse pregnancy outcomes in Yazd, a central province of Iran. J Reprod Infertil 2016; 17: 34-38.
34. [34] Faghih S, Abdolahzadeh M, Mohammadi M, Hasanzadeh J. Prevalence of vitamin d deficiency and its related factors among university students in shiraz, iran. Int J Prev Med 2014; 5: 796. (Persian).
35. [35] Bhat M, Ismail A. Vitamin D treatment protects against and reverses oxidative stress induced muscle proteolysis. J Steroid Biochem Mol Biol 2015; 152: 171-179. [DOI:10.1016/j.jsbmb.2015.05.012] [PMID]
36. [36] Zhang HQ, Teng JH, Li Y, Li XX, He YH, He X, et al. Vitamin D status and its association with adiposity and oxidative stress in schoolchildren. Nutrition 2014; 30: 1040-1044. [DOI:10.1016/j.nut.2014.02.024] [PMID]
37. [37] Dzik K, Skrobot W, Flis DJ, Karnia M, Libionka W, Kloc W, et al. Vitamin D supplementation attenuates oxidative stress in paraspinal skeletal muscles in patients with low back pain. Eur J Appl Physiol 2018; 118: 143-151. [DOI:10.1007/s00421-017-3755-1] [PMID]
38. [38] Jungert A, Neuhäuser-Berthold M. Cross-sectional and longitudinal associations between serum 25‑hydroxyvitamin D and anti-oxidative status in older adults. Exp Gerontol 2018; 110: 291-297. [DOI:10.1016/j.exger.2018.06.024] [PMID]
39. [39] Boaventura BC, Cembranel F. Chapter 35 - Protective effect of vitamin D on oxidative stress in elderly people. In: Preedy VR, Patel VB, editors. Aging (Second Edition): Academic Press; 2020; p: 337-343. [DOI:10.1016/B978-0-12-818698-5.00036-5]
40. [40] Tohari AM, Zhou X, Shu X. Protection against oxidative stress by vitamin D in cone cells. Cell Biochem Funct 2016; 34: 82-94. [DOI:10.1002/cbf.3167] [PMID]
41. [41] Samimi M, Kashi M, Foroozanfard F, Karamali M, Bahmani F, Asemi Z, et al. The effects of vitamin D plus calcium supplementation on metabolic profiles, biomarkers of inflammation, oxidative stress and pregnancy outcomes in pregnant women at risk for pre‐eclampsia. J Hum Nutr Diet 2016; 29: 505-515. [DOI:10.1111/jhn.12339] [PMID]
42. [42] Gargari BP, Tabrizi FP, Sadien B, Jafarabadi MA, Farzadi L. Vitamin D status is related to oxidative stress but not high-sensitive C-reactive protein in women with pre-eclampsia. Gynecol Obstet Invest 2016; 81: 308-314. [DOI:10.1159/000441781] [PMID]
43. [43] Berridge MJ. Vitamin D: a custodian of cell signalling stability in health and disease. Biochem Soc Trans 2015; 43: 349-358. [DOI:10.1042/BST20140279] [PMID]
44. [44] Berridge MJ. Vitamin D cell signalling in health and disease. Biochem Biophys Res Commun 2015; 460: 53-71. [DOI:10.1016/j.bbrc.2015.01.008] [PMID]
45. [45] Berridge MJ. Vitamin D, reactive oxygen species and calcium signalling in ageing and disease. Philos Trans R Soc Lond B Biol Sci 2016; 371: 20150434. [DOI:10.1098/rstb.2015.0434] [PMID] [PMCID]
46. [46] Wiseman H. Vitamin D is a membrane antioxidant Ability to inhibit iron‐dependent lipid peroxidation in liposomes compared to cholesterol, ergosterol and tamoxifen and relevance to anticancer action. FEBS Lett 1993; 326: 285-288. [DOI:10.1016/0014-5793(93)81809-E]
47. [47] Mohammed MA, Aboulhoda BE, Mahmoud RH. Vitamin D attenuates gentamicin-induced acute renal damage via prevention of oxidative stress and DNA damage. Hum Exp Toxicol 2019; 38: 321-335. [DOI:10.1177/0960327118812166] [PMID]
48. [48] Xu S, Chen YH, Tan ZX, Xie DD, Zhang C, Xia MZ, et al. Vitamin D3 pretreatment alleviates renal oxidative stress in lipopolysaccharide-induced acute kidney injury. J Steroid Biochem Mol Biol 2015; 152: 133-141. [DOI:10.1016/j.jsbmb.2015.05.009] [PMID]
49. [49] Almasmoum H, Refaat B, Ghaith MM, Almaimani RA, Idris S, Ahmad J, et al. Protective effect of Vitamin D3 against lead induced hepatotoxicity, oxidative stress, immunosuppressive and calcium homeostasis disorders in rat. Environ Toxicol Pharmacol 2019; 72: 103246. [DOI:10.1016/j.etap.2019.103246] [PMID]
50. [50] Moore C, Murphy MM, Keast DR, Holick MF. Vitamin D intake in the United States. J Am Diet Assoc 2004; 104: 980-983. [DOI:10.1016/j.jada.2004.03.028] [PMID]

Ethics code: IR.KMU.REC.1395.551
Clinical trials code: IRCT201609026026N4


XML   English Abstract   Print



بازنشر اطلاعات
Creative Commons License این مقاله تحت شرایط Creative Commons Attribution-NonCommercial 4.0 International License قابل بازنشر است.
جلد 23، شماره 6 - ( آذر و دی 1400 ) برگشت به فهرست نسخه ها