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Relationship between complete blood count indices with the severity of disease in patients with chronic obstructive pulmonary disease
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Farhad Malek   , Jafar Alaavi Toussy , Tayebeh Khajeali |
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Abstract: (6149 Views) |
| Introduction: Chronic obstructive pulmonary disease (COPD)
is one of the common and increasing causes of mortality and morbidity.
Considering the inflammatory nature and the known complications of this
disease, in the present study the relationship between complete blood count
(CBC) parameters and disease severity has been investigated. Materials and Methods: In the present study, 48 COPD patients and 48
healthy individuals underwent spirometry with or without bronchodilator. For
CBC, fasting blood samples were obtained from all the participants. Results and
supplementary information were recorded in questionnaires. Results: White blood cell (WBC) counts were
significantly higher in COPD patients compared to the control group (P=0.012).
However, there was no significant difference between low and high stages of the
disease (P=0.449). Absolute and relative neutrophils counts were also
significantly higher in COPD patients than the control group (P=0.005 and
P=0.035, respectively). In high stages of COPD, relative neutrophils count was
significantly higher compared to that of the low stages (P=0.004). Our results
showed no significant differences in platelets, hemoglobin and mean platelet
volume (MPV) between COPD patients and control group and also between the
different stages of COPD. Conclusion: In the present study, we observed
higher WBC and absolute and relative neutrophils counts in COPD patients
compared to the control, which is consistent with the inflammatory nature of
the disease. Furthermore, relative neutrophils count was related to COPD
severity |
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| Keywords: Chronic obstructive pulmonary disease, Cell blood count, Severity of illness index |
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Full-Text [PDF 643 kb]
(1511 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2014/03/12 | Accepted: 2014/12/11 | Published: 2014/12/11
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