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Effect of carnosine on cerebral edema and oxidative stress biomarkers in a transient model of focal cerebral ischemia in rats
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Abedin Vakili   , Ahmad Reza Bandegi , Saeed Baiati , Roya Hassanzadeh , Yasin Asadi |
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Abstract: (7312 Views) |
| Introduction: Carnosine is an endogenous dipeptide expressed in many tissues including
brain and has a protective effect against ischemic brain damage. However, its
effect on brain edema, which is one of the most important variables in
determining the amount of secondary brain damage after stroke, is not clear.
The present study was conducted to investigate the effect of L-Carnosine on
brain edema and oxidative stressbiomarkers in an experimental model of focal
cerebral ischemia. Materials and Methods: Under Laser Doppler flowmetry, cerebral ischemia was induced by transient
occlusion of middle cerebral artery for 1 hour in rats. L-Carnosine at doses of
250 and 500 mg/kg.ip was injected immediately after induction of ischemia.
Cerebral edema and enzymes activity of superoxide dismutase (SOD), glutathione
peroxidase (GPx) and malondialdehyde (MDA) content were measured 24 hours after
ischemia using a standard method and kit. Results: Administration of L-Carnosine at doses 250(%81.5±0.36)
and 500 (%80.9±0.30) mg/kg significantly reduced brain edema by 25% and 40% in
comparison with the control group (%82.53±0.16), respectively (P |
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| Keywords: Carnosine, Brain Ischemia, Brain edema, Oxidative stress, Rats |
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Full-Text [PDF 343 kb]
(1775 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2013/07/16 | Accepted: 2013/12/17 | Published: 2014/06/11
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