اکثر مکاتبات کومش از طریق ایمیل سایت می باشد. لطفا Spam ایمیل خود را نیز چک نمایید.
   [Home ] [Archive]   [ فارسی ]  
:: ::
Main Menu
Home::
Journal Information::
Articles archive::
For Authors::
Subscription::
Contact us::
Site Facilities::
Webmail::
Editorial Board::
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
:: Volume 15, Issue 4 (تابستان 1393: 15 (4) 1393) ::
Koomesh 1393, 15(4): 493-501 Back to browse issues page
Effect of carnosine on cerebral edema and oxidative stress biomarkers in a transient model of focal cerebral ischemia in rats
Abedin Vakili , Ahmad Reza Bandegi , Saeed Baiati , Roya Hassanzadeh , Yasin Asadi
Abstract:   (7288 Views)
 Introduction: Carnosine is an endogenous dipeptide expressed in many tissues including brain and has a protective effect against ischemic brain damage. However, its effect on brain edema, which is one of the most important variables in determining the amount of secondary brain damage after stroke, is not clear. The present study was conducted to investigate the effect of L-Carnosine on brain edema and oxidative stressbiomarkers in an experimental model of focal cerebral ischemia. Materials and Methods: Under Laser Doppler flowmetry, cerebral ischemia was induced by transient occlusion of middle cerebral artery for 1 hour in rats. L-Carnosine at doses of 250 and 500 mg/kg.ip was injected immediately after induction of ischemia. Cerebral edema and enzymes activity of superoxide dismutase (SOD), glutathione peroxidase (GPx) and malondialdehyde (MDA) content were measured 24 hours after ischemia using a standard method and kit. Results: Administration of L-Carnosine at doses 250(%81.5±0.36) and 500 (%80.9±0.30) mg/kg significantly reduced brain edema by 25% and 40% in comparison with the control group (%82.53±0.16), respectively (P
Keywords: Carnosine, Brain Ischemia, Brain edema, Oxidative stress, Rats
Full-Text [PDF 343 kb]   (1761 Downloads)    
Type of Study: Research | Subject: General
Received: 2013/07/16 | Accepted: 2013/12/17 | Published: 2014/06/11
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Vakili A, Bandegi A R, Baiati S, Hassanzadeh R, Asadi Y. Effect of carnosine on cerebral edema and oxidative stress biomarkers in a transient model of focal cerebral ischemia in rats. Koomesh 1393; 15 (4) :493-501
URL: http://koomeshjournal.semums.ac.ir/article-1-2145-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 15, Issue 4 (تابستان 1393: 15 (4) 1393) Back to browse issues page
کومش Koomesh
Persian site map - English site map - Created in 0.14 seconds with 38 queries by YEKTAWEB 4645