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Role of increasing serum tumor necrosis factor on hyperalgesia and edema variation during different stages of adjuvant- induced arthritis in male rats
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Zeinab اختری   , Jalal زرین قلم , Akram عیدی , A. li حائری روحانی , Elaheh تکیه |
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Abstract: (11659 Views) |
| Introduction: Tumor necrosis factor α (TNF-α) is a potent cytokine that exerts
pleiotropic functions in inflammatory symptoms. With regarding to the important
role of TNFα in hyperalgesia and edema induction via intra-cellular signaling
pathways, we aimed to investigate the role of increasing serum TNF-α on
hyperalgesia and edema and spinal mu opioid receptor (mOR) expression variation
during different stages of Complete Freound Adjuvant- induced arthritis in male
rats. Materials and Methods: Mono-arthritis was
induced by CFA and then inflammatory symptoms (hyperalgesia and edema) were
assessed on day 0, 3,7th, 14 and 21 following CFAinduction. In addition,
anti-TNF-α was daily administered for 21 days for all different experimental
groups. Spinal mOR expression were detected by western blotting. Results: Our results showed that anti-TNFα
administration in AA group resulted in decrease of paw volume and hyperalgesia until day 14,
whereas, those symptoms were increased on day 21 following CFAinduction. Our
study stated that anti- TNFα antibody administration causes a significant
decreasing in spinal mOR protein expression on days 14 and 21 of the study. Conclusion: This study confirmed the
time-dependent and bi-directional effects of serum TNF-α levsel on CFA-induced
hyperalgesia, which it can say, a portion of these effects might be mediated
via spinal mOR expression variation. |
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| Keywords: Hyperalgesia, Edema, Tumor necrosis factor-alpha, Receptors, Opioid, Mu |
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Full-Text [PDF 1021 kb]
(2138 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2012/03/19 | Accepted: 2013/04/8 | Published: 2013/04/8
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