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:: جلد 24، شماره 2 - ( ویژه نامه پزشکی فرد محور- فروردین و اردیبهشت 1401 ) ::
جلد 24 شماره 2 صفحات 282-276 برگشت به فهرست نسخه ها
بررسی عوامل ژنتیکی مرتبط با سندرم تخمدان پلی‌کیستیک
یودیت اوهب ، مژگان اسدی* ، نگار سرهنگی ، مهسا محمد آملی
چکیده:   (343 مشاهده)
هدف: سندرم تخمدان پلی‌کیستیک (PCOS) یکی از رایج‌ترین اختلالات غدد درون‌ریز و عامل 75 درصد ناباروری ناشی از اختلالات تخمک‌گذاری در سنین باروری به‌شمار می‌رود. زنان مبتلا به PCOS با الیگومنوره و عوارض ازدیاد آندوژن‌ها مواجه هستند که بر روی کیفیت زندگی و باروری آن‌ها به‌طور هم‌زمان اثرگذار است. این سندرم سال‌هاست که به یکی از بحث برانگیزترین مباحث در در رابطه با غدد درون‌ریز تبدیل شده است. تحقیقات امروزه حاکی از آن است که این سندرم یک بیماری وراثتی است و ژن‌هایی در آن دخیل هستند که به نسل بعد انتقال میابند. نتیجه‌ی این تحقیقات که در سراسر جهان بر روی هزاران زن انجام شده است، نشان می‌دهد که بیان برخی از ژن‌ها تغییر یافته است. ژن‌هایی که مورد بررسی قرار گرفته‌اند مسئول سنتز هورمون‌های استروئیدی و تنظیم عملکرد آن‌ها، تنظیم گنادوتروپین‌ها، سنتز و عملکرد انسولین هستند. اگرچه هنوز علت اساسی بیماری‌زایی PCOS مشخص نیست اما شواهد مبتنی بر نقش عوامل ژنتیکی، سبک زندگی، تغذیه و آلودگی‌های محیطی در شکل‌گیری این بیماری وجود دارد. از این‌رو امید است درمان این سندرم ناهمگون با کمک پزشکی فرد‌محور بهبود یابد. مطالعات تکمیلی بیش‌تری باید انجام شود تا ارتباط بین عوامل مختلفی که ممکن است دارای نقش فعال بیماری‌زایی در PCOS  باشند را دریابند.
 
واژه‌های کلیدی: سندرم تخمدان پلی‌کیستیک، ژنتیک، غدد درون‌ریز، پزشکی فرد‌محور
متن کامل [PDF 910 kb]   (77 دریافت)    
نوع مطالعه: مروري | موضوع مقاله: مروري
دریافت: 1400/6/1 | پذیرش: 1400/9/24 | انتشار: 1400/12/28
فهرست منابع
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Oheb Y, Asadi M, Sarhangi N, Mohamad Amoli M. Investigation of genetic factors associated with polycystic ovary syndrome. Koomesh. 2022; 24 (2) :276-282
URL: http://koomeshjournal.semums.ac.ir/article-1-7237-fa.html

اوهب یودیت، اسدی مژگان، سرهنگی نگار، محمد آملی مهسا. بررسی عوامل ژنتیکی مرتبط با سندرم تخمدان پلی‌کیستیک. كومش. 1401; 24 (2) :282-276

URL: http://koomeshjournal.semums.ac.ir/article-1-7237-fa.html



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