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ویروس درمانی سرطان‌ها: هدف‌گیری سلول‌های سرطانی به‌وسیله مکانیسم microRNA به منظور تکثیر انتخابی ویروس‌های لیزکننده تومور در این سلول‌ها
احسان کاکاوندی ، محمد شایسته پور* ، شراره مقیم
چکیده:   (527 مشاهده)
سرطان به عنوان یکی از جدی‌ترین مشکلات بهداشت عمومی، دومین علت مرگ و میر در جهان بعد از بیماری‌های قلبی عروقی محسوب می‌شود. تعداد مبتلایان به این بیماری و مرگ و میر ناشی از آن به طور روزافزونی در سراسر دنیا در حال افزایش است، لذا تشخیص زود‌هنگام، پیشگیری و درمان مناسب سرطان اهمیت فراوانی دارد. درمان‌های رایج مانند شیمی‌درمانی و پرتودرمانی، اغلب به صورت غیرانتخابی عمل کرده و عوارض جانبی فراوانی دارند. استفاده از ویروس‌های لیزکننده تومور (ویروس‌درمانی)، روشی جدید برای درمان سرطان است. معضل روش ویروس‌درمانی غیر انتخابی بودن تکثیر ویروس در سلول‌های سرطانی است بدین مفهوم که ویروس در سلول‌های نرمال هم همانندسازی می‌کند. در سال‌های اخیر برای مهار همانندسازی ویروس در سلول‌های سالم و انتخابی کردن تکثیر آن در تومورها، از روش‌های مختلفی استفاده شده است که روش هدف‌گیری (miRNA) microRNA جدیدترین متد است. این مقاله مروری، جنبه‌های مختلف انتخابی کردن تکثیر ویروس‌های لیزکننده تومور به وسیله مکانیسم هدف‌گیری miRNA را مورد بررسی قرار می‌دهد
واژه‌های کلیدی: ویروس‌های لیزکننده تومور، سرطان، میکرو آر ان ای
متن کامل [PDF 853 kb]   (117 دریافت)    
نوع مطالعه: مروري | موضوع مقاله: مروري
دریافت: 1400/3/11 | پذیرش: 1400/6/29 | انتشار: 1401/2/30
فهرست منابع
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Kakavandi E, Shayestehpour M, Moghim S. Cancer virotherapy: Targeting cancer cells by microRNA mechanism for selective replication of oncolytic viruses in these cells. Koomesh. 2022; 24 (3) :288-299
URL: http://koomeshjournal.semums.ac.ir/article-1-7091-fa.html

کاکاوندی احسان، شایسته پور محمد، مقیم شراره. ویروس درمانی سرطان‌ها: هدف‌گیری سلول‌های سرطانی به‌وسیله مکانیسم microRNA به منظور تکثیر انتخابی ویروس‌های لیزکننده تومور در این سلول‌ها. كومش. 1401; 24 (3) :299-288

URL: http://koomeshjournal.semums.ac.ir/article-1-7091-fa.html



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کومش Koomesh
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