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جلد 23 شماره 5 صفحات 654-664 برگشت به فهرست نسخه ها
تأثیر تزریق دو طرفه ایبوتونیک اسید در ناحیه نئواستریاتوم و ورزش اجباری بر یادگیری و حافظه فضایی و ویژگی‌های آنتروپومتریک موش‌های صحرایی نر
شقایق مدبری ، مهدی شهبازی ، ناصر نقدی ، فضل الله باقرزاده
چکیده:   (317 مشاهده)
هدف: استریاتوم ورودی اصلی عقده‌های قاعده‌ای است و آسیب آن باعث ایجاد اختلال در رفتارهای شناختی و حرکتی می‌شود. برخی شواهد نشان داده‌اند که ورزش  می‌تواند اختلالات شناختی به ویژه یادگیری و حافظه ناشی از آسیب‌های مغزی را جبران کند. پژوهش حاضر بررسی تأثیر تخریب دو طرفه ناحیه نئواستریاتوم عقده‌های قاعده‌‌ای با استفاده از تزریق دوطرفه ایبوتونیک اسید و نیز ورزش اجباری بر حافظه فضایی و ویژگی‌های آنتروپومتریک موش‌های صحرایی نر بود.
مواد و روشها: در این پژوهش 48 سر موش صحرایی نر به صورت تصادفی در شش گروه (کنترل، شم جراحی، جراحی، ورزش، شم جراحی و ورزش، جراحی و ورزش) تقسیم شدند. تخریب دو طرفه ناحیه استریاتوم عقده‌های قاعده‌‌ای با استفاده از تزریق دوطرفه ایبوتونیک اسید انجام شد. گروه‌های ورزشی به مدت 4 هفته روی یک تردمیل ورزش کردند.
یافتهها: یافته‌ها نشان داد که تزریق ایبوتونیک اسید در ناحیه نئواستریاتوم منجر به تخریب و کاهش معنی‌دار یادگیری و حافظه فضایی در مقایسه با گروه سالم شده است (05/0>P). ورزش اجباری نتوانست اختلال یادگیری و حافظه فضایی ناشی از تخریب استریاتوم را به طور معنی‌داری بهبود بخشد (05/0<P). از طرفی چهار هفته ورزش اجباری توانست در گروه تخریبی دو فاکتور وزن و طول بدن رت‌ها را بهبود بخشد (03/0=P).
نتیجهگیری: نتایج نشان داد استریاتوم بر یادگیری و حافظه فضایی نقش حیاتی دارد در حالی‌که چهار هفته ورزش اجباری نتوانست آثار تخریب استریاتوم بر یادگیری و حافظه فضایی را بهبود بخشد.
 
واژه‌های کلیدی: آنتروپومتری، تردمیل، عقده‌های قاعده‌ای، یادگیری، حافظه فضایی
متن کامل [PDF 1292 kb]   (71 دریافت)    
نوع مطالعه: پژوهشي | موضوع مقاله: عمومى
دریافت: 1399/6/3 | پذیرش: 1399/12/25 | انتشار: 1400/7/6
فهرست منابع
1. [1] Smith Y, Galvan A. Non-human primate research of basal ganglia and movement disorders: advances and challenges. J Neural Transm (Vienna) 2018. [DOI:10.1007/s00702-018-1849-5] [PMID] [PMCID]
2. [2] Bhatia D. A study on basal ganglia circuit and its relation with movement disorders. Oncol Based Inform Retriev Health Syst 2020; 19-35. [DOI:10.1002/9781119641391.ch2]
3. [3] Ilinsky I, Jouandet M, Goldman‐Rakic P. Organization of the nigrothalamocortical system in the rhesus monkey. J Comp Neurol 1985; 236: 315-330. [DOI:10.1002/cne.902360304] [PMID]
4. [4] Modaberi S, Shahbazi M, Naghdi N, Bagherzadeh A. The effects of mild forced treadmill exercise and GABA-B agonist on locomotor activity and anxiety-behavior in rats with striatum dysfunction. Annal Appl Sport Sci 2017; 5: 39-47. [DOI:10.29252/aassjournal.5.4.39]
5. [5] Simonyan K, Cho H, Hamzehei Sichani A, Rubien-Thomas E, Hallett M. The direct basal ganglia pathway is hyperfunctional in focal dystonia. Brain 2017; 140: 3179-3190. [DOI:10.1093/brain/awx263] [PMID] [PMCID]
6. [6] Calabresi P, Picconi B, Tozzi A, Ghiglieri V. Interaction between basal ganglia and limbic circuits in learning and memory processes. Parkinsonism Relat Disord 2016; 22: S65-S68. [DOI:10.1016/j.parkreldis.2015.09.017] [PMID]
7. [7] Goodman J, Packard M. Memory systems of the basal ganglia. Handbook of Behavioral Neuroscience. 24: Elsevier; 2016; p: 725-740. [DOI:10.1016/B978-0-12-802206-1.00035-0]
8. [8] Ou CY, Luo YN, He SN, Deng XF, Luo HL, Yuan ZX, et al. Sodium P-Aminosalicylic acid improved manganese-induced learning and memory dysfunction via restoring the ultrastructural alterations and γ-Aminobutyric acid metabolism imbalance in the basal ganglia. Biol Trace Elem Res 2017; 176: 143-153. [DOI:10.1007/s12011-016-0802-4] [PMID]
9. [9] Ferbinteanu J. Contributions of hippocampus and striatum to memory-guided behavior depend on past experience. J Neuroscience 2016; 36: 6459-6470. [DOI:10.1523/JNEUROSCI.0840-16.2016] [PMID] [PMCID]
10. [10] Pahng AR, Colombo PJ. Phosphorylation of tyrosine receptor kinase B in the dorsal striatum and dorsal hippocampus is associated with response learning in a water plus maze. Behav Neuros 2017; 131: 33. [DOI:10.1037/bne0000177] [PMID]
11. [11] Vong L, Ye C, Yang Z, Choi B, Chua Jr S, Lowell BB. Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons. Neuron 2011; 71: 142-154. [DOI:10.1016/j.neuron.2011.05.028] [PMID] [PMCID]
12. [12] Meister B. Neurotransmitters in key neurons of the hypothalamus that regulate feeding behavior and body weight. Physiol Behav 2007; 92: 263-271. [DOI:10.1016/j.physbeh.2007.05.021] [PMID]
13. [13] Abbott CR, Kennedy AR, Wren AM, Rossi M, Murphy KG, Seal LJ, et al. Identification of hypothalamic nuclei involved in the orexigenic effect of melanin-concentrating hormone. Endocrinology 2003; 144: 3943-3949. [DOI:10.1210/en.2003-0149] [PMID]
14. [14] Clegg DJ, Air EL, Benoit SC, Sakai RS, Seeley RJ, Woods SC. Intraventricular melanin-concentrating hormone stimulates water intake independent of food intake. Am J Physiol Regul Integr Comp Physiol 2003; 284: R494-R499. [DOI:10.1152/ajpregu.00399.2002] [PMID]
15. [15] Qu D, Ludwig DS, Gammeltoft S, Piper M, Pelleymounter MA, Cullen MJ, et al. A role for melanin-concentrating hormone in the central regulation of feeding behaviour. Nature 1996; 380: 243-247. [DOI:10.1038/380243a0] [PMID]
16. [16] Rossi M, Beak SA, Choi SJ, Small CJ, Morgan DG, Ghatei MA, et al. Investigation of the feeding effects of melanin concentrating hormone on food intake-action independent of galanin and the melanocortin receptors. Brain Res 1999; 846: 164-170. [DOI:10.1016/S0006-8993(99)02005-3]
17. [17] Campbell JN, Macosko EZ, Fenselau H, Pers TH, Lyubetskaya A, Tenen D, et al. A molecular census of arcuate hypothalamus and median eminence cell types. Nat Neuros 2017; 20: 484-496. [DOI:10.1038/nn.4495] [PMID] [PMCID]
18. [18] Kim ER, Wu Z, Sun H, Xu Y, Mangieri LR, Xu Y, et al. Hypothalamic non-AgRP, non-POMC GABAergic neurons are required for postweaning feeding and NPY hyperphagia. J Neuroscience 2015; 35: 10440-10450. [DOI:10.1523/JNEUROSCI.1110-15.2015] [PMID] [PMCID]
19. [19] Nakamura Y, Ikuta T. Caudate-precuneus functional connectivity is associated with obesity preventive eating tendency. Brain Connect 2017; 7: 211-217. [DOI:10.1089/brain.2016.0424] [PMID]
20. [20] Carnell S, Gibson C, Benson L, Ochner C, Geliebter A. Neuroimaging and obesity: current knowledge and future directions. Obes Rev 2012; 13: 43-56. [DOI:10.1111/j.1467-789X.2011.00927.x] [PMID] [PMCID]
21. [21] Pursey KM, Stanwell P, Callister RJ, Brain K, Collins CE, Burrows TL. Neural responses to visual food cues according to weight status: a systematic review of functional magnetic resonance imaging studies. Front Nutr 2014; 1: 7. [DOI:10.3389/fnut.2014.00007] [PMID] [PMCID]
22. [22] Schlögl H, Horstmann A, Villringer A, Stumvoll M. Functional neuroimaging in obesity and the potential for development of novel treatments. Lancet Diabetes Endocrinol 2016; 4: 695-705. [DOI:10.1016/S2213-8587(15)00475-1]
23. [23] Val-Laillet D, Aarts E, Weber B, Ferrari M, Quaresima V, Stoeckel L, et al. Neuroimaging and neuromodulation approaches to study eating behavior and prevent and treat eating disorders and obesity. Neuroimage Clin 2015; 8: 1-31. [DOI:10.1016/j.nicl.2015.03.016] [PMID] [PMCID]
24. [24] Shohamy D, Myers C, Kalanithi J, Gluck M. Basal ganglia and dopamine contributions to probabilistic category learning. Neurosci Biobehav Rev 2008; 32: 219-236. [DOI:10.1016/j.neubiorev.2007.07.008] [PMID] [PMCID]
25. [25] Frank MJ, Loughry B, O'Reilly RC. Interactions between frontal cortex and basal ganglia in working memory: a computational model. Cogn Affect Behav Neurosci 2001; 1: 137-160. [DOI:10.3758/CABN.1.2.137] [PMID]
26. [26] Liljeholm M, O'Doherty JP. Anything you can do, you can do better: neural substrates of incentive-based performance enhancement. PLoS Biol 2012; 10: e1001272. [DOI:10.1371/journal.pbio.1001272] [PMID] [PMCID]
27. [27] Bäckman L, Nyberg L, Soveri A, Johansson J, Andersson M, Dahlin E, et al. Effects of working-memory training on striatal dopamine release. Science 2011; 333: 718. [DOI:10.1126/science.1204978] [PMID]
28. [28] Chatham CH, Frank MJ, Badre D. Corticostriatal output gating during selection from working memory. Neuron 2014; 81: 930-942. [DOI:10.1016/j.neuron.2014.01.002] [PMID] [PMCID]
29. [29] Suyama S, Yada T. New insight into GABAergic neurons in the hypothalamic feeding regulation. J Physiol Sci 2018; 68: 717-722. [DOI:10.1007/s12576-018-0622-8] [PMID]
30. [30] Wang P, Zhang G. Hypothalamic AgRP neurons and the regulation of appetite and body weight: A review. Chin Sci Bullet 2018; 63: 3059-3069. [DOI:10.1360/N972018-00413]
31. [31] Fan B, Jabeen R, Bo B, Guo C, Han M, Zhang H, et al. What and how can physical activity prevention function on Parkinson's disease? Oxid Med Cell Longev 2020; 2020. [DOI:10.1155/2020/4293071] [PMID] [PMCID]
32. [32] Feng YS, Yang SD, Tan ZX, Wang MM, Xing Y, Dong F, et al. The benefits and mechanisms of exercise training for Parkinson's disease. Life Sci 2020; 245: 117345. [DOI:10.1016/j.lfs.2020.117345] [PMID]
33. [33] Ferreira AFF, Binda KH, Singulani MP, Pereira CPM, Ferrari GD, Alberici LC, et al. Physical exercise protects against mitochondria alterations in the 6-hidroxydopamine rat model of Parkinson's disease. Behav Brain Res 2020; 112607. [DOI:10.1016/j.bbr.2020.112607] [PMID]
34. [34] Oliveira LOD, da Silva PIC, Rodrigues Filho RP, Progênio RCS, de Oliveira VDPS, Silva RC, et al. Prior exercise protects against oxidative stress and motor deficit in a rat model of Parkinson's disease. Metab Brain Dis 2020; 35: 175-181. [DOI:10.1007/s11011-019-00507-z] [PMID]
35. [35] Johansson H, Hagströmer M, Grooten WJ, Franzén E. Exercise-Induced neuroplasticity in parkinson's disease: a metasynthesis of the literature. Neural Plast 2020; 2020: 8961493. [DOI:10.1155/2020/8961493] [PMID] [PMCID]
36. [36] Valenti MT, Dalle Carbonare L, Dorelli G, Mottes M. Effects of physical exercise on the prevention of stem cells senescence. Stem Cell Rev Rep 2020; 16: 33-40. [DOI:10.1007/s12015-019-09928-w] [PMID]
37. [37] Goodyear MD, Krleza-Jeric K, Lemmens T. The declaration of Helsinki. Br Med J Publish Group 2007. [DOI:10.1136/bmj.39339.610000.BE] [PMID] [PMCID]
38. [38] Zeman A, Hoefeijzers S, Milton F, Dewar M, Carr M, Streatfield C. The GABAB receptor agonist, baclofen, contributes to three distinct varieties of amnesia in the human brain-A detailed case report. Cortex 2016; 74: 9-19. [DOI:10.1016/j.cortex.2015.10.005] [PMID]
39. [39] Karthick C, Periyasamy S, Jayachandran KS, Anusuyadevi M. Intrahippocampal administration of ibotenic acid induced cholinergic dysfunction via NR2A/NR2B expression: implications of resveratrol against Alzheimer disease pathophysiology. Front Mol Neurosci 2016; 9: 28. [DOI:10.3389/fnmol.2016.00028] [PMID] [PMCID]
40. [40] Babar E, Özgünen T, Melikov E, Polat S, Kaya M. The median raphe nucleus lesion attenuates amnesic effects of ketamine on short-term memory in rats. J Islamic Acad Sci 1994; 7: 241-246.
41. [42] Kim SH, Kim HB, Jang MH, Lim BV, Kim YJ, Kim YP, et al. Treadmill exercise increases cell proliferation without altering of apoptosis in dentate gyrus of Sprague-Dawley rats. Life Sci 2002; 71: 1331-1340. [DOI:10.1016/S0024-3205(02)01849-0]
42. [43] Whishaw IQ, Mittleman G, Bunch ST, Dunnett SB. Impairments in the acquisition, retention and selection of spatial navigation strategies after medial caudate-putamen lesions in rats. Behav Brain Res 1987; 24: 125-138. [DOI:10.1016/0166-4328(87)90250-6]
43. [44] Vorhees CV, Williams MT. Morris water maze: procedures for assessing spatial and related forms of learning and memory. Nat Protoc 2006; 1: 848. [DOI:10.1038/nprot.2006.116] [PMID] [PMCID]
44. [45] Azimi M, Gharakhanlou R, Naghdi N, Khodadadi D, Heysieattalab S. Moderate treadmill exercise ameliorates amyloid-β-induced learning and memory impairment, possibly via increasing AMPK activity and up-regulation of the PGC-1α/FNDC5/BDNF pathway. Peptides 2018; 102: 78-88. [DOI:10.1016/j.peptides.2017.12.027] [PMID]
45. [46] Lee B, Sur BJ, Kwon S, Jung E, Shim I, Lee H, et al. Acupuncture stimulation alleviates corticosterone-induced impairments of spatial memory and cholinergic neurons in rats. Evid Based Complement Alternat Med 2012; 2012: 670536. [DOI:10.1155/2012/670536] [PMID] [PMCID]
46. [47] Shahbazi M SM, Naghdi N, Farokhi A, Kazem Nejad A, Tahmasebi SH. The effect of two types of diet (zinc deficiency and iron deficiency) on some anthropometric indices (height and weight), brain growth and motor function of young rats. Motor Sport Growth Learn (movement) 2009; 1: 5-25. (Persian).
47. [48] Namavar M, Bahmanpour S. Effect of cyclosporine on weight and crown-rump length of mice embryo. Indian J Pharmace Sci 2007; 69: 582. [DOI:10.4103/0250-474X.36953]
48. [49] Zhou Y, Zhu Q, Ma W, Xia B, Xiao X, Zhao Y, et al. Prenatal vanadium exposure, cytokine expression, and fetal growth: A gender-specific analysis in Shanghai MCPC study. Sci Total Environ 2019; 685: 1152-1159. [DOI:10.1016/j.scitotenv.2019.06.191] [PMID]
49. [50] Beroun A, Mitra S, Michaluk P, Pijet B, Stefaniuk M, Kaczmarek L. MMPs in learning and memory and neuropsychiatric disorders. Cell Mol Life Sci 2019; 1-22. [DOI:10.1007/s00018-019-03180-8] [PMID] [PMCID]
50. [51] Packard MG, Knowlton BJ. Learning and memory functions of the basal ganglia. Annu Rev Neurosci 2002; 25: 563-593. [DOI:10.1146/annurev.neuro.25.112701.142937] [PMID]
51. [52] Can SM, Barlas O. Improvement of spatial learning and memory impairments by fetal neural tissue transplantation in experimental rat model of Alzheimer's disease. Bagcılar Med Bull Bağcılar Tıp Bülteni 2019; 4: 67. [DOI:10.4274/BMB.galenos.2019.07.012]
52. [53] Carmack, S. A., Koob, G. F., & Anagnostaras, S. G. (2017). Learning and Memory in Addiction. [DOI:10.1016/B978-0-12-809324-5.21101-2]
53. [54] Moseley, Rachel. "The limbic system." (2018): 964-966.
54. [55] da Costa Daniele TM, de Bruin PFC, de Matos RS, de Bruin GS, Junior CMC, de Bruin VMS. Exercise effects on brain and behavior in healthy mice, Alzheimer's disease and Parkinson's disease model-A systematic review and meta-analysis. Behav Brain Res 2020; 383: 112488. [DOI:10.1016/j.bbr.2020.112488] [PMID]
55. [56] Garcia PC, Real CC, Ferreira AF, Alouche SR, Britto LR, Pires RS. Different protocols of physical exercise produce different effects on synaptic and structural proteins in motor areas of the rat brain. Brain Res 2012; 1456: 36-48. [DOI:10.1016/j.brainres.2012.03.059] [PMID]
56. [57] Snigdha S, Prieto G. Exercise enhances cognitive capacity in the aging brain. Physical activity and the aging brain: Elsevier 2017; p: 161-172. [DOI:10.1016/B978-0-12-805094-1.00016-2]
57. [58] Wanner P, Winterholler M, Gassner H, Winkler J, Klucken J, Pfeifer K, et al. Acute exercise following skill practice promotes motor memory consolidation in parkinson's disease. Neurobiol Learn Mem 2021; 178: 107366. [DOI:10.1016/j.nlm.2020.107366] [PMID]
58. [59] ZeidAbadi R AE, Naghdi N, Bluri R. The effect of short-term and long-term physical activity with very low intensity on learning and spatial memory in mice. J Motor Behav 2014; 6: 155-172 (Persian).
59. [60] Potter MC, Yuan C, Ottenritter C, Mughal M, van Praag H. Exercise is not beneficial and may accelerate symptom onset in a mouse model of Huntington's disease. PLoS Curr 2010; 2. [DOI:10.1371/currents.RRN1201] [PMID] [PMCID]
60. [61] Murray DK, Sacheli MA, Eng JJ, Stoessl AJ. The effects of exercise on cognition in Parkinson's disease: a systematic review. Transl Neurodegener 2014; 3: 5. [DOI:10.1186/2047-9158-3-5] [PMID] [PMCID]
61. [62] McDonald RJ, White NM. A triple dissociation of memory systems: hippocampus, amygdala, and dorsal striatum. Behav Neurosci 1993; 107: 3. [DOI:10.1037/0735-7044.107.1.3]
62. [63] Orgeta V, McDonald KR, Poliakoff E, Hindle JV, Clare L, Leroi I. Cognitive training interventions for dementia and mild cognitive impairment in Parkinson's disease. Cochrane Database Syst Rev 2020. [DOI:10.1002/14651858.CD011961.pub2] [PMID] [PMCID]
63. [64] Sanders L, Hortobágyi T, Karssemeijer E, Van der Zee E, Scherder E, Van Heuvelen M. Effects of low-and high-intensity physical exercise on physical and cognitive function in older persons with dementia: a randomized controlled trial. Alzheimers Res Ther 2020; 12: 1-15. [DOI:10.1186/s13195-020-00597-3] [PMID] [PMCID]
64. [65] Welch AC, Zhang J, Lyu J, McMurray MS, Javitch JA, Kellendonk C, et al. Dopamine D2 receptor overexpression in the nucleus accumbens core induces robust weight loss during scheduled fasting selectively in female mice. Mol Psychiatry 2019; 10. [DOI:10.1038/s41380-019-0633-8] [PMID] [PMCID]
65. [66] Frank GK, Bailer UF, Henry SE, Drevets W, Meltzer CC, Price JC, et al. Increased dopamine D2/D3 receptor binding after recovery from anorexia nervosa measured by positron emission tomography and [11c] raclopride. Biol Psychiatry 2005; 58: 908-912. [DOI:10.1016/j.biopsych.2005.05.003] [PMID]
66. [67] Duncan L, Yilmaz Z, Gaspar H, Walters R, Goldstein J, Anttila V, et al. Significant locus and metabolic genetic correlations revealed in genome-wide association study of anorexia nervosa. Am J Psychiatry 2017; 174: 850-858. [DOI:10.1176/appi.ajp.2017.16121402] [PMID] [PMCID]
67. [68] Watson HJ, Yilmaz Z, Thornton LM, Hübel C, Coleman JR, Gaspar HA, et al. Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa. Nat Genet 2019; 51: 1207-1214. [DOI:10.1038/s41588-019-0439-2] [PMID] [PMCID]
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Modaberi S, Shahbazi M, Naghdi N, Bagherzadeh F. Effects of bilateral microinjections of ibotenic acid into neostriatal region and forced exercise on spatial learning and memory and anthropometric characteristics of male rats. Koomesh. 2021; 23 (5) :654-664
URL: http://koomeshjournal.semums.ac.ir/article-1-6580-fa.html

مدبری شقایق، شهبازی مهدی، نقدی ناصر، باقرزاده فضل الله. تأثیر تزریق دو طرفه ایبوتونیک اسید در ناحیه نئواستریاتوم و ورزش اجباری بر یادگیری و حافظه فضایی و ویژگی‌های آنتروپومتریک موش‌های صحرایی نر. كومش. 1400; 23 (5) :654-664

URL: http://koomeshjournal.semums.ac.ir/article-1-6580-fa.html



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