TY - JOUR JF - Koomesh JO - Koomesh VL - 21 IS - 1 PY - 1397 Y1 - 1397/10/01 TI - Correlation between serum levels of RANKL with osteoporosis in patients with beta thalassemia major TT - ارتباط بین غلظت سرمی RANKL با استئوپورزیس در بیماران مبتلا به بتا تالاسمی ماژور N2 - Introduction: Osteoporosis is a major problem in patients with B-thalassemia major. Osteoclasts hyperactivity, which increases serum levels of receptor activator of nuclear factor kappa-Β ligand (RANKL), plays an important role in the pathogenesis of osteoporosis in these patients. The aim of this study was to study the relationship between serum levels of RANKL and osteoporosis in patients with beta thalassemia major. Materials and Methods: 52 patients with beta thalassemia major and 22 people with thalassemia minor without any osteoporosis symptoms as controls were entered the study.  Six ml of peripheral blood was obtained for hematologic and serum RANKL measurements. Results: The mean of bone mineral density in patients were 0.57 ± 0.3 and 0.69 ± 0.11 in femur and vertebra, respectively.  There were significant differences between hematologic parameters of patients and controls. The mean of patient’s serum RANKL level was 198.4pg/mL and in controls was 112.25pg/mL. There was a correlation between decrease of femur BMD (p SP - 150 EP - 154 AU - Jafari, Fatemeh AU - Azarkeivan, Azita AU - Bashash, Davod AU - Khadem Maboodi, Ali Akbar AU - Hamidpour, Mohsen AD - Dept. of Hematology and Blood Banking, Hemopoeitic Stem cell Research Center (HSCRC), School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran KW - B- Thalassemia Major KW - Osteoporosis KW - Hematologic Parameters KW - RANKL UR - http://koomeshjournal.semums.ac.ir/article-1-4790-en.html ER -