RT - Journal Article T1 - Anti-proliferative effects of new synthesized hydrazone derivatives on breast, colon and hepatic cancer cells JF - Koomesh YR - 1397 JO - Koomesh VO - 20 IS - 4 UR - http://koomeshjournal.semums.ac.ir/article-1-3861-en.html SP - 725 EP - 730 K1 - Cytotoxic K1 - Chemotherapy K1 - Hydrazones K1 - Carcinoma Cell Line K1 - Neoplasms AB - Introduction: Despite the advances made in research on cancer, there is still no effective way to treat this condition. A number of compounds including hydrazone derivatives have been increasingly investigated as anticancer agents. So, in this study a series of novel hydrazone derivatives were designed and synthesized as potential anticancer compounds and their cytotoxic effects were further evaluated. Materials and Methods: The designed hydrazone compounds (1-9) were synthesized in three steps and their structures were characterized by different instrumental analysis methods. The cytotoxic activity was measured using MTT assay at 48 and 72 h on human breast, colon and liver cancer cell lines. Results: The obtained percentage of cytotoxicity indicated that some compounds were potent against cancer cell lines and the most effective incubation time was after 72 h of treeatment. Among the synthesized compounds, compounds 3 and 6 revealed the considerable cytotoxic activity on breast, liver and colon cells after 72 h of treatment ranging from 60 to 80%. Conclusion: The results obtained in this section can be used as the starting point for the development of new cancer chemotherapy agents LA eng UL http://koomeshjournal.semums.ac.ir/article-1-3861-en.html M3 ER -