TY - JOUR T1 - Investigation of phylogenetic diversity among Eschereshia coli isolates recovered from hospitalized patients TT - بررسی تنوع فیلوژن‍تیکی ایزوله‌های کلینیکی اشرشیاکلی به‌دست آمده از بیماران بستری JF - Koomesh JO - Koomesh VL - 19 IS - 1 UR - http://koomeshjournal.semums.ac.ir/article-1-3279-en.html Y1 - 1395 SP - 207 EP - 212 KW - Eschereshia coli KW - Bacterial Drug Resistance KW - Phylogeny N2 - Introduction: Eschereshia coli (E.coli) as one of the major cause of infections in hospital settings can be classified into phylogenetic groups which are different in virulence, growth rates and antibiotic susceptibility patterns. In this study, we aimed to perform phylogenetic analysis in E.coli strains to understand association between phylogroups and antibiotic susceptibility patterns. Materials and Methods: Two hundred and sixty E. coli isolates recovered from hospitalized patients at Kosar teaching hospital in Semnan city, Iran were subjected to phylogenetic typing by a quadruplex PCR method. Antimicrobial susceptibility testing was also performed by disk agar diffusion method. Results: Phylogroup B2 was the most predominant phylogroup (38.4%) followed by A (14.8%), F (13.4%), D (9.3%), B1 (8.8%), C and E (4.6%), unknown (4.2%), and clade I (1.9%). We found 70.4% of our isolates were multiple drug resistant (MDR). The most and the least efficient antibiotics were meropenem and trimethoprime/sulfamethoxazole with 94.4% and 27.8% of susceptibility rates, respectively. Conclusion: Our results represent the high prevalence of MDR E. coli isolates with dominance of phylogroup B2. Phylogroup B2 not only could be considered as a virulent phylogroup but also as a genetic antibiotic resistance reservoir. M3 ER -