RT - Journal Article T1 - Spirulina Plathensis microalgae prevents scopolamine-induced memory impairment in young female Wistar rats JF - Koomesh YR - 1398 JO - Koomesh VO - 21 IS - 3 UR - http://koomeshjournal.semums.ac.ir/article-1-5042-en.html SP - 549 EP - 556 K1 - Avoidance Learning K1 - Memory K1 - Scopolamine K1 - Memory Disorders K1 - Scopolamine K1 - Spirulina K1 - Oxidative Stress AB - Introduction: Memory deficit is one of the clinical problems of Alzheimer’s disease that progressively leads to cognitive impairment and dementia. In the present study, the effect of Spirulina plathensis microalgae on the scopolamine-induced memory impairment was evaluated. Materials and Methods: Young female Wistar rats (30 days old) were used. Animals randomly were divided into 9 groups (Saline + Saline, Saline + Scopolamine 1mg/kg, Saline + Scopolamine 2 mg/kg, Spirulina 100 mg/kg + Scopolamine 2 mg/kg, Spirulina 200 mg/kg + Scopolamine 2 mg/kg, Spirulina 400 mg/kg + Scopolamine 2 mg/kg, Spirulina 100 mg/kg + Saline, Spirulina 200 mg/kg + Saline, Spirulina 400 mg/kg + Saline). To measure inhibitory avoidance (IA) task, animals were given an electrical footshock (0.5 mA, 3 s) and then was intraperitoneally treated by scopolamine and 24 latter memory retention tests (time delay to re-entrance to dark compartment) was recorded. Spirulina plathensis was dissolved in physiologic saline and the suspension was gavaged at doses of 100, 200, and 400 mg/kg for fourteen days prior to training. Biochemical experiments were included determination of Malondialdehyde (MDA) and total antioxidant capacity of serum using thiobarbituric acid and Ferric reducing ability of plasma (FRAP), respectively Results: Our results showed that scopolamine (2 mg/kg) significantly (P LA eng UL http://koomeshjournal.semums.ac.ir/article-1-5042-en.html M3 ER -